Heavy Lynch Syndrome Men at Risk for Colorectal Adenomas

Association found only in men with no history of colorectal cancer neoplasms

THURSDAY, Aug. 26 (HealthDay News) -- Men with Lynch syndrome (LS) and a body mass index (BMI) of 25 kg/m² or more may be at increased risk for developing colorectal adenomas, according to research published online Aug. 23 in the Journal of Clinical Oncology.

Akke Botma, of Wageningen University in the Netherlands, and colleagues examined data on 486 patients with LS, evenly divided between those who had and those who did not have a history of colorectal cancer (CRC) neoplasms, to determine whether there is an association between BMI and colorectal adenoma occurrence in LS patients.

The researchers found a significant association between being overweight (BMI of 25 kg/m² or more) and risk of developing colorectal adenomas in men with no history of CRC neoplasms (hazard ratio, 8.72 for overweight versus normal weight), but not in men with a history of CRC neoplasms or in women in either cohort. Also, in men with a history of CRC neoplasms, height was significantly associated with a decreased risk of adenomatous polyps (hazard ratio per 5 cm increase, 0.43).

"In summary, our results suggest that BMI is associated with the incidence of colorectal adenomas in men with LS. We did not observe an association between BMI and the development of recurrent or new primary colorectal adenomas. If confirmed, overweight may be an important modifiable risk factor for colorectal adenoma incidence in men with LS," the authors write.

One author disclosed a consulting or advisory relationship with Sensus.

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