FRIDAY, March 18 (HealthDay News) -- Uterine risk factors (RF) strongly influence survival of women with endometrial cancer, independent of nodal metastasis, according to research published in the March issue of the American Journal of Obstetrics & Gynecology.
Nicanor I. Barrena Medel, M.D., from the Columbia University College of Physicians and Surgeons in New York City, and colleagues compared the prognostic value of uterine RF with nodal metastases in 26,967 women with stage I to IIIC endometrial cancer. The participants were stratified into five groups based on the presence or absence of lymph node involvement and the number of RF present (myoinvasion greater than or equal to 50 percent, cervical stromal involvement, and grade 3 histology).
The investigators found that, although both nodal disease and uterine RF strongly influenced survival, the negative prognostic influence of nodal disease was more significant. The five-year overall survival rate of participants with positive node and no RF was 68 percent, compared to 69 percent in participants who were node negative with multiple RF. Node-positive patients with RF had a lower five-year survival rate than node-positive patients with no RF (58 versus 68 percent).
"We noted that uterine RF are important determinants of survival for women with endometrial cancer independent of nodal status," the authors write. "Even in the presence of nodal metastases, uterine RF continue to negatively impact survival."