Higher Maternal Lipid Profile Tied to Congenital Heart Disease in Offspring
Doubled risk seen for high triglyceride, total/high-density lipoprotein, and apolipoprotein-A1
FRIDAY, Aug. 20, 2021 (HealthDay News) -- An elevated maternal lipid profile is associated with an increased risk for congenital heart disease (CHD) in offspring, according to a study published online Aug. 3 in Acta Obstetricia et Gynecologica Scandinavica.
Li Cao, from the Children's Hospital of Fudan University in Shanghai, and colleagues assessed whether maternal blood lipid levels during the first trimester are associated with the occurrence of CHD in offspring. The analysis included 230 mothers of offspring with CHD and 381 without CHD.
The researchers found that levels of triglyceride, apolipoprotein-A1, and apolipoprotein-B in early pregnancy were significantly higher in the CHD group compared with the control group. Triglyceride (odds ratio, 2.46), total/high-density lipoprotein cholesterol (odds ratio, 2.10), and apolipoprotein-A1 (odds ratio, 2.73) were positively associated with CHD risk in offspring in multivariate analyses.
"Based on current knowledge, it is helpful to encourage lifestyle intervention strategies such as regular exercise, healthy diet, and weight control that may improve the lipid profile in the preconception period and early pregnancy, which may achieve better health in offspring," the authors write.