HIV Therapy Doesn't Affect Blood Glucose in Pregnancy

Protease inhibitors do not increase the risk of failing blood glucose tolerance tests

THURSDAY, May 4 (HealthDay News) -- HIV-infected pregnant women, whether or not they are taking protease inhibitors, are no more likely to develop glucose intolerance than HIV-negative women, according to a report published in the May issue of the Obstetrics & Gynecology.

Jeanne S. Sheffield, M.D., of the University of Texas Southwestern Medical Center at Dallas, and colleagues studied data on 171 HIV-infected pregnant women between January 1, 1998 and January 8, 2004 who had one-hour and three-hour glucose tolerance tests, and compared the results with HIV-negative controls.

Overall, 12 percent of the HIV-infected women had abnormal one-hour glucola test results and 3 percent had abnormal three-hour results. The results were similar in women who were HIV-negative. Forty-five percent of the HIV-infected women were taking protease inhibitors at the time of the test, and therapy status did not affect the results, the researchers report.

"Glucose intolerance in this obstetric population was not associated with the diagnosis of HIV or with the use of protease inhibitors," the authors write. "Protease inhibitors should continue to be an option for the treatment of HIV in pregnancy."

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