FRIDAY, June 5, 2020 (HealthDay News) -- COVID-19 patients with hypertension have increased mortality risk, with significantly higher risk among those without antihypertensive treatment, according to a study published online June 4 in the European Heart Journal.
Chao Gao, from Xijing Hospital in Xi'an, China, and colleagues conducted a retrospective study of patients with COVID-19 admitted to Huo Shen Shan Hospital in Wuhan, China, to examine whether hypertension treatment influences mortality.
The researchers found that 29.5 percent of the 2,877 hospitalized patients had a history of hypertension. Patients with hypertension had a significantly increased relative risk for mortality compared with those without hypertension after adjustment for confounders (adjusted hazard ratio [HR], 2.12; 95 percent confidence interval [CI], 1.17 to 3.82; P = 0.013). A significantly higher risk for mortality was seen among patients with a history of hypertension but without antihypertensive treatment compared with those with antihypertensive treatments (HR, 2.17; 95 percent CI, 1.03 to 4.57; P = 0.041). Mortality rates were similar for those receiving a renin-angiotensin-aldosterone system (RAAS) inhibitor and non-RAAS inhibitor (HR, 0.85; 95 percent CI, 0.28 to 2.58; P = 0.774). In a meta-analysis of four studies, patients with RAAS inhibitor use tended to have a reduced mortality risk (relative risk, 0.65; 95 percent CI, 0.45 to 0.94; P = 0.02).
"Due to the observational nature of the study, the results should be interpreted cautiously and considered as no obvious additional risk to continue RAAS inhibitors in patients with COVID-19 infection," the authors write.