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BetaPV Infection Tied to SCC in Transplant Recipients

Significant association between betapapillomavirus infection and SCC in transplant recipients

MONDAY, July 18 (HealthDay News) -- There is a significant association between betapapillomavirus (betaPV) infection and squamous cell carcinoma (SCC) in patients who receive organ transplants, according to a study published in the July issue of the American Journal of Transplantation.

Charlotte M. Proby, M.B.B.S., from the Queen Mary University of London, and colleagues investigated the association between betaPV infection and SCC in 210 patients with previous history of SCC who received organ transplants, and 394 controls without skin cancer. Human papillomavirus (HPV) DNA genotyping assay was used to determine the presence of 25 betaPV types in plucked eyebrow hairs, and multiplex serology was used to reveal antibodies for the 15 most prevalent betaPV types. Multivariate logistic regression models were used to predict associations between various measures of betaPV infection and SCC.

The investigators found that both the organ transplant group and the control group had high prevalence of multiple types of betaPV DNA (>94 percent). There was a significant correlation between SCC and the simultaneous detection of both DNA and antibodies for at least one type of betaPV (adjusted odds ratio [OR], 1.6). Borderline significant associations were found between SCC and HPV36 (adjusted OR, 2.4; 95 percent confidence interval 1.0 to 5.4), and similar correlations were found for HPV5, HPV9, and HPV24.

"These data provide further evidence of an association between betaPV infection and SCC in organ transplant recipients," the authors write.

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