Registry Can Reduce CRE Carriers, CRE Prevalence

Incident carriers, prevalence of CRE reduced even when only 25 percent of facilities participate


FRIDAY, May 10, 2019 (HealthDay News) -- The implementation of a registry can reduce the spread of carbapenem-resistant Enterobacteriaceae (CRE), even when only a proportion of facilities participate, according to a study published online May 9 in Clinical Infectious Diseases.

Bruce Y. Lee, M.D., from the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues developed an agent-based model of all inpatient health care facilities in the Chicago metropolitan area, surrounding area, and patient flow. The impact of a registry that tracked patients carrying CRE to help guide infection prevention and control was explored in different scenarios.

The researchers found that the registry reduced the number of new carriers by 11.7 percent and reduced CRE prevalence by 7.6 percent during a three-year period when all 402 Illinois facilities participated. Registry use resulted in an 11.6 percent relative reduction in new carriers (16.9 and 1.2 percent in participating and nonparticipating facilities, respectively) and a 5.0 percent relative reduction in prevalence when 75 percent of the largest Illinois facilities participated. There were relative reductions of 10.7 and 5.6 percent in incident carriers and prevalence, respectively, when 50 percent participated and relative reductions of 9.1 (20.4 and 1.6 percent in participants and nonparticipating facilities, respectively) and 2.8 percent, respectively, when 25 percent participated.

"We found that a registry can provide independent effects of disease prevention, even before additional public health prevention measures are implemented," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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