See What HealthDay Can Do For You
Contact Us

Effect of Different Vaccines in H5N1 Pandemic Compared

Vaccine formulation with low antigen dose, non-aluminum adjuvant may be best option

THURSDAY, July 23 (HealthDay News) -- Vaccines against H5N1 influenza containing non-aluminum adjuvant might be the best formulation for immunizing the public in the event of a pandemic, according to research published in the August issue of The Lancet Infectious Diseases.

Lamberto Manzoli, M.D., of the University "G. d'Annunzio" of Chieti in Italy, and colleagues analyzed data from a meta-analysis that included 13 randomized controlled trials assessing 58 groups, which evaluated the effects of avian H5N1 vaccination.

The researchers found that vaccines with non-aluminum adjuvant elicited sufficiently high immunogenicity -- more than 70 percent -- even at low doses, such as 12 μg or less given as two doses. Higher doses didn't lead to substantial improvements. Aluminum-adjuvanted and non-adjuvanted vaccines showed lower immunogenicity, and even high doses didn't provide sufficient immunogenicity.

"Taken together, these findings suggest that, at present, the H5N1 vaccine formulation that includes a low antigen dose and a non-aluminum adjuvant (which, at such doses, is an oil-in-water emulsion-based adjuvant) might represent the best option in the case of a pandemic. Considering that lowest-dose vaccines would be strongly needed to allow rapid production and supply during a pandemic (an issue that is likely to be crucial because recourse to antiviral agents might be limited by suboptimum stocks and distribution logistics), a vaccine including 6 μg or lower and oil-in-water adjuvant could be a very useful option," the authors conclude.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.