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Risk Factors Identified for Catheter-Related Thrombosis

Implanted ports decrease risk compared to peripherally implanted central venous catheters

MONDAY, March 7 (HealthDay News) -- The risk of catheter-related thrombosis (CRT) is decreased by use of implanted ports and increased by previous history of deep vein thrombosis, insertion into the subclavian vein, and improper catheter tip position, according to a review published in the February issue of the Journal of Thrombosis and Haemostasis.

Wael Saber, M.D., from the University of Wisconsin School of Medicine and Public Health in Madison, and colleagues reviewed seven prospective studies and five randomized clinical trials published between 1995 and 2008 to identify the risk factors for CRT and identify high risk patients who should receive thromboprophylaxis. The trials and studies represented 5,636 patients, who had 425 CRT events.

The investigators found that the use of implanted ports decreased CRT risk compared to peripherally implanted central venous catheters (odds ratio [OR], 0.43). An increased CRT risk was found to be associated with three factors: past history of deep vein thrombosis (OR, 2.03), subclavian venipuncture insertion technique (OR, 2.16), and improper catheter tip location (OR, 1.92).

"We identified four independent risk factors for CRT using individual patient-level data from prospective studies. Validation of the results could lead to the development of risk stratification models that will help to tailor prophylaxis therapy in cancer patients with indwelling central venous catheters," the authors write.

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