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Bisphenol A Exposure Not Linked to Type 2 Diabetes

New study doesn't confirm link between urinary bisphenol A levels and type 2 diabetes

TUESDAY, Sept. 20 (HealthDay News) -- Urinary bisphenol A (BPA) levels are not associated with self-reported type 2 diabetes, according to a study published in the Sept. 20 issue of the Annals of Internal Medicine.

Guang Ning, M.D., Ph.D., from the Shanghai Jiao-Tong University School of Medicine in China, and colleagues investigated the association between BPA exposure and type 2 diabetes in adults. A total of 3,423 adults aged 40 years or older (1,087 with type 2 diabetes) were enrolled in the study from May 2008 to August 2009. BPA urinary concentration from morning spot urine samples, fasting plasma glucose concentration, plasma glucose concentration two hours after an oral glucose tolerance test, and serum insulin concentration were measured.

The investigators found that the median urinary BPA level was 0.81 ng/mL. Different clinical characteristics were seen for participants with normal glucose regulation and those with impaired glucose regulation, and by BPA quartile. In multivariable analysis, there was no distinct correlation between BPA levels and type 2 diabetes. Participants in the second (0.48 to 0.81 ng/mL) and fourth (>1.43 ng/mL) BPA quartiles showed a slightly increased odds ratio [OR] for type 2 diabetes (adjusted OR, 1.30 and 1.37, respectively), but not those in the third quartile (0.82 to 1.43 ng/mL); the trend of the association was not statistically significant.

"The findings do not confirm a previously reported association between urinary BPA levels and self-reported type 2 diabetes," the authors write.

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