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September 2012 Briefing - Internal Medicine

Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for September 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

SNPs Linked to Erectile Dysfunction After Radiotherapy

FRIDAY, Sept. 28 (HealthDay News) -- Twelve single nucleotide polymorphisms (SNPs) are associated with development of erectile dysfunction (ED) following radiotherapy for prostate cancer, according to a study published online Sept. 28 in the International Journal of Radiation Oncology*Biology*Physics.

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History of Sexual Abuse Slows Response to Bariatric Surgery

FRIDAY, Sept. 28 (HealthDay News) -- Although studies suggest that individuals with a history of sexual abuse may experience less weight loss soon after bariatric surgery, most individuals still benefit from the surgical procedure, with increased weight loss seen over time, according to research published in the October issue of Obesity Reviews.

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Standards for Diabetes Education, Support Updated

FRIDAY, Sept. 28 (HealthDay News) -- A task force from the American Association of Diabetes Educators and the American Diabetes Association has updated the national standards for diabetes self-management education and support, according to a report published online Sept. 20 in Diabetes Care.

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Benzodiazepine Use Linked to Increased Risk of Dementia

FRIDAY, Sept. 28 (HealthDay News) -- New use of benzodiazepines correlates with an increase in the risk of dementia, according to a study published online Sept. 27 in BMJ.

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Simple Form Identifies Ovarian Cancer Warning Signs

FRIDAY, Sept. 28 (HealthDay News) -- A simple, quick, easy-to-use paper form can help identify symptoms potentially indicative of ovarian cancer in women treated in the primary care clinic setting, according to research published in the September issue of the Open Journal of Obstetrics and Gynecology.

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Many Support Financial Incentives for Organ Donation

FRIDAY, Sept. 28 (HealthDay News) -- At least 40 percent of Canadians consider it acceptable to offer financial incentives to encourage kidney donation, according to a study published online Sept. 27 in the Clinical Journal of the American Society of Nephrology.

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New Transplant Platform Successful in Sickle Cell

THURSDAY, Sept. 27 (HealthDay News) -- Non-myeloablative conditioning with post-transplantation high-dose cyclophosphamide expands the donor pool for bone marrow transplantation for patients with sickle cell disease, according to a preliminary study published online Sept. 6 in Blood.

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Pediatric Kidney Disease Tied to Abnormal Carotid Arteries

THURSDAY, Sept. 27 (HealthDay News) -- Ultrasound measurements of carotid intima-media thickness (cIMT) are significantly elevated among children with chronic kidney disease (CKD) compared with healthy controls, according to a study published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

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Study Supports Diet High in Total Antioxidants for Lower MI Risk

THURSDAY, Sept. 27 (HealthDay News) -- A diet high in total antioxidant capacity, based on fruits, vegetables, coffee, and whole grains, is associated with a lower risk of myocardial infarction, according to a study published in the October issue of The American Journal of Medicine.

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In Treated MS, Early Disease Activity Predicts Poor Outcome

THURSDAY, Sept. 27 (HealthDay News) -- After 15 years of follow-up, patients with relapsing-remitting multiple sclerosis (RRMS) who display disease activity despite treatment with interferon (IFN)β-1a tend to have unfavorable long-term outcomes, according to research published online Sept. 13 in the Annals of Neurology.

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Complementary Medicine Superior to Usual PTSD Therapy

THURSDAY, Sept. 27 (HealthDay News) -- A complementary medicine intervention of healing touch with guided imagery (HT+GI) reduces post-traumatic stress disorder (PTSD) and related symptoms in returning combat-exposed active duty military personnel, according to a study published in the September issue of Military Medicine.

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Insulin Sensitivity Lower in Adults Born Preterm

THURSDAY, Sept. 27 (HealthDay News) -- Middle-aged adults who were born preterm, even moderately preterm (32 to 36 weeks' gestation), are less insulin sensitive compared with adults who were born at term, according to research published in the October issue of Diabetes.

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Choice of Psoriasis Treatment Affects CVD Event Rates

THURSDAY, Sept. 27 (HealthDay News) -- Compared with other anti-psoriatic therapies, systemic anti-inflammatory treatment of patients with severe psoriasis with biologic agents or methotrexate is associated with a lower combined risk of death, myocardial infarction, and stroke, according to research published online Sept. 11 in the Journal of Internal Medicine.

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Being Deemed 'Unfit to Drive' Cuts Subsequent Road Crashes

WEDNESDAY, Sept. 26 (HealthDay News) -- Medical warnings to patients who are potentially unfit to drive correlate with a reduction in the number of road crashes in which the patient is a driver, according to a study published in the Sept. 27 issue of the New England Journal of Medicine.

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Conditional Reprogramming Can Help ID Pathogenic Viruses

WEDNESDAY, Sept. 26 (HealthDay News) -- Conditional reprogramming can be successfully used to generate cell cultures from normal and tumor tissue of a patient with papillomatosis, facilitating identification of a mutant human papillomavirus (HPV) and allowing appropriate treatment, according to a study published in the Sept. 27 issue of the New England Journal of Medicine.

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Trio of Studies Look at Impact of Sugary Drinks on Weight

FRIDAY, Sept. 21 (HealthDay News) -- For adults, children, and teens, drinking sugar-sweetened beverages correlates with increases in body mass index (BMI) and obesity, according to three studies published online Sept. 21 in the New England Journal of Medicine to coincide with presentation at the annual meeting of The Obesity Society, held from Sept. 20 to 24 in San Antonio, Texas.

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Antibiotic Use Varies by Season, Geographic Region for Elderly

WEDNESDAY, Sept. 26 (HealthDay News) -- Antibiotic usage among older adults varies widely by geographical region and season, according to a study published online Sept. 24 in the Archives of Internal Medicine.

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Drugs Similar in Efficacy for Neuropathic Pain in Diabetes

WEDNESDAY, Sept. 26 (HealthDay News) -- In the treatment of patients with chronic diabetic peripheral neuropathic pain (DPNP), there are no significant differences in pain-relief efficacy between amitriptyline, duloxetine, and pregabalin; however, pregabalin improves sleep continuity and duloxetine improves daytime functioning, according to research published online Sept. 18 in Diabetes Care.

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Medicare Knee Replacement Numbers Up Over Last 20 Years

TUESDAY, Sept. 25 (HealthDay News) -- From 1991 to 2010 there was a 161.5 percent annual volume increase in primary total knee arthroplasty (TKA) among Medicare enrollees as well as an increase in per capita utilization, according to research published in the Sept. 26 issue of the Journal of the American Medical Association.

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Marijuana-Like Chemical Corrects Behavior in Fragile X

TUESDAY, Sept. 25 (HealthDay News) -- The protein lost in fragile X syndrome, the most common genetic cause of autism, is part of a complex that, when targeted by a drug that boosts a natural marijuana-like chemical in the brain, corrects some of the behavioral abnormalities in mice, according to a study published online Sept. 25 in Nature Communications.

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Sporadic Jakob-Creutzfeldt Disease Often Misdiagnosed

TUESDAY, Sept. 25 (HealthDay News) -- Patients with sporadic Jakob-Creutzfeldt disease (sCJD) are often misdiagnosed, with only 18 percent correctly diagnosed at their first assessment, according to a study published online Sept. 24 in the Archives of Neurology.

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Guidelines Issued for Improving Outcomes for ICD Recipients

TUESDAY, Sept. 25 (HealthDay News) -- Patient and family education and psychological support are key components for improving outcomes for implantable cardioverter defibrillator (ICD) recipients, according to a scientific statement issued by the American Heart Association and published online Sept. 24 in Circulation.

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Stress-Weight Link in Black and White Teen Girls Studied

TUESDAY, Sept. 25 (HealthDay News) -- Increased stress is tied to weight gain in teenage girls, particularly black girls, according to a study published online Sept. 20 in the Annals of Behavioral Medicine.

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Bacteriophages of P. acnes Have Limited Genetic Diversity

TUESDAY, Sept. 25 (HealthDay News) -- Bacteriophages that infect the dominant bacteria inhabitant of the human sebaceous follicle, Propionibacterium acnes (P. acnes), which contributes to the pathogenesis of acne, have limited genetic diversity and display a broad host range, according to a study published online Sept. 25 in mBio.

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Study Examines Prevalence of Local Allergic Rhinitis

TUESDAY, Sept. 25 (HealthDay News) -- Local allergic rhinitis (LAR) is prevalent among patients with rhinitis, affecting about one in four, and is often associated with childhood onset and persistent, severe conjunctivitis and/or asthma, according to a study published in the October issue of Allergy.

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Leadership Inversely Associated With Stress Levels

MONDAY, Sept. 24 (HealthDay News) -- Leaders have lower levels of cortisol and lower reports of anxiety, with a dose-response association seen for levels of leadership, which seems to be mediated by a sense of control, according to a study published online Sept. 24 in the Proceedings of the National Academy of Sciences.

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Surveillance for Low-Risk Prostate Cancer Examined

MONDAY, Sept. 24 (HealthDay News) -- For men with low-risk prostate cancer, projections show that active surveillance may result in a modest decline in prostate cancer-specific survival, but allows men to remain treatment-free for several more years compared with immediate radical prostatectomy, according to a study published online Sept. 24 in Clinical Cancer Research.

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Effect of Behavioral Intervention on Alcohol Misuse Evaluated

MONDAY, Sept. 24 (HealthDay News) -- Behavioral counseling interventions may be beneficial for adults with risky drinking behaviors, according to a review and meta-analysis published online Sept. 25 in the Annals of Internal Medicine.

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Deaths Due to Poisoning, Suicide, Falls Up in Last Decade

MONDAY, Sept. 24 (HealthDay News) -- Deaths due to suicide, falls, and unintentional poisoning increased over the last decade, while motor vehicle accident deaths declined by 25 percent, according to research published online Sept. 20 in the American Journal of Public Health.

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Skin Cancer Incidence Up After Pancreas Transplantation

FRIDAY, Sept. 21 (HealthDay News) -- Nonmelanoma skin cancers (NMSCs) commonly occur after pancreas transplantation (PT), particularly in those who have a history of skin cancer, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

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Fewer Older People on the Street May Lead Youth to Riskier Lives

FRIDAY, Sept. 21 (HealthDay News) -- There is a difference in the age profile of people observed on the streets in affluent and deprived neighborhoods, which is not always reflective of the actual age profile of the community and may influence life-history strategies, according to a study published in the September issue of Human Nature.

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Central Centrifugal Cicatricial Alopecia Pathogenesis Studied

FRIDAY, Sept. 21 (HealthDay News) -- Protease-activated receptor 2 (PAR-2), which is activated by cowhage, may play a role in central centrifugal cicatricial alopecia (CCCA), the most common cause of scarring hair loss in African-American women, according to research published online Sept. 17 in the British Journal of Dermatology.

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Safe for Intravenous Catheters to Be Replaced As Needed

FRIDAY, Sept. 21 (HealthDay News) -- Replacement of peripheral intravenous catheters as clinically indicated is as safe as routine replacement, according to a study published in the Sept. 22 issue of The Lancet, a theme issue on surgery.

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Urge to Overeat Linked to Production of Natural Narcotic

FRIDAY, Sept. 21 (HealthDay News) -- When presented with tasty foods, the brain produces the opioid peptide enkephalin that stimulates an unexpected reward center in the brain and leads to overeating, according to a study published online Sept. 20 in Current Biology.

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Increased Prevalence of Obesity in Rural Areas

FRIDAY, Sept. 21 (HealthDay News) -- Rates of obesity are significantly higher among rural adults compared with urban residents, according to a study published in The Journal of Rural Health.

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Perceived Stress Linked to Asthma, Atopic Disorders

FRIDAY, Sept. 21 (HealthDay News) -- Perceived stress correlates with an increased risk of adult-onset asthma, allergic rhinitis, and atopic dermatitis as well as asthma medication use, according to a study published online Sept. 3 in Allergy.

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Health Benefits Seen for Moving to Less Poor Neighborhood

THURSDAY, Sept. 20 (HealthDay News) -- Moving from a high-poverty to a lower-poverty neighborhood correlates with long-term improvements in physical and mental health and subjective well-being, according to a study published in the Sept. 21 issue of Science.

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Channel Blockers Reduce Causes of Asthma Symptoms

THURSDAY, Sept. 20 (HealthDay News) -- Epithelial expression of the calcium-activated chloride channel (CaCC) TMEM16A is increased in patients with asthma, and its inhibition negatively regulates epithelial mucin secretion and airway smooth muscle contraction, according to a study published online Sept. 17 in the Proceedings of the National Academy of Sciences.

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Stress-Reducing Effect of Acute Exercise Persists

THURSDAY, Sept. 20 (HealthDay News) -- The anxiety-lowering effect of exercise seems to persist even after exposure to emotional stimuli, according to a study published online Aug. 14 in Medicine & Science in Sports & Exercise.

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Drug Improves Social Function in Fragile X Syndrome

THURSDAY, Sept. 20 (HealthDay News) -- A γ-aminobutyric acid type B (GABAB) agonist, STX209 (Arbaclofen), can significantly improve social function in patients with fragile X syndrome, according to a study published in the Sept. 19 issue of Science Translational Medicine.

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Thin Placenta at Birth Ups Risk of Sudden Cardiac Death Later

THURSDAY, Sept. 20 (HealthDay News) -- Sudden cardiac death in adults is associated with placental size at birth, with a significantly increased risk of death for decreased placental thickness, according to a study published online Sept. 19 in the International Journal of Epidemiology.

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Sequential Oral, Topical Tacrolimus Benefits Dermatitis

THURSDAY, Sept. 20 (HealthDay News) -- Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis (AD), according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

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Duration of Antiplatelet Drugs for Drug-Eluting Stents Studied

THURSDAY, Sept. 20 (HealthDay News) -- In patients receiving drug-eluting stents, dual antiplatelet therapy can be safely discontinued during the first year, according to two studies published online Sept. 19 in the Journal of the American College of Cardiology.

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Linaclotide Relieves Symptoms of IBS With Constipation

THURSDAY, Sept. 20 (HealthDay News) -- Over 26 weeks of treatment, the peptide guanylate cyclase-C agonist linaclotide significantly improves abdominal pain and bowel symptoms in patients with irritable bowel syndrome with constipation (IBS-C), according to research published online Sept. 18 in the American Journal of Gastroenterology.

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Emotional Neglect in Childhood Ups Stroke Risk in Adults

THURSDAY, Sept. 20 (HealthDay News) -- Emotional neglect as a child may be tied to a higher risk of stroke as an adult, according to a study published online Sept. 19 in Neurology.

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African-Americans Less Adherent to DASH Diet for Lowering BP

THURSDAY, Sept. 20 (HealthDay News) -- Greater adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is associated with larger reductions in blood pressure (BP), independent of weight loss; however, African-Americans are less likely to adhere to the DASH diet, according to a study published online Sept. 19 in the Journal of the Academy of Nutrition and Dietetics.

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AHA: Sesame, Rice Oil Blend Lowers Blood Pressure

THURSDAY, Sept. 20 (HealthDay News) -- Daily use of a blend of sesame and rice bran oils can significantly lower blood pressure and lipids in patients with hypertension, according to a study presented at the American Heart Association's High Blood Pressure Research Scientific Sessions, held from Sept. 19 to 22 in Washington, D.C.

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Nonmedical School Vaccination Exemptions Increasing

WEDNESDAY, Sept. 19 (HealthDay News) -- Nonmedical exemptions for school vaccination requirements have increased since 2005, particularly in states with easy exemption policies, according to a letter to the editor published in the Sept. 20 issue of the New England Journal of Medicine.

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Alcohol-Related Esophageal Cancer Risk Is Reversible

WEDNESDAY, Sept. 19 (HealthDay News) -- The alcohol-related effects on esophageal cancer risk are reversible with cessation of alcohol consumption, according to research published in the July issue of Addiction.

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Suspected Viruses Don't Cause Chronic Fatigue Syndrome

WEDNESDAY, Sept. 19 (HealthDay News) -- There is no relationship between chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and either xenotropic murine leukemia virus-related virus (XMRV) or polytropic murine leukemia virus (pMLV), according to a study published online Sept. 18 in mBio.

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Nearly Half of European Mortality Due to Cancer, Chronic Disease

WEDNESDAY, Sept. 19 (HealthDay News) -- Deaths from cancer and chronic diseases accounted for approximately 42 percent of deaths in 2007 across the European Union (EU), according to a study published online Aug. 28 in BMJ Supportive & Palliative Care.

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More Cardio-Related Life Years Lost at Extreme Temperatures

WEDNESDAY, Sept. 19 (HealthDay News) -- Cold spells and heat waves increase the number of life years lost from cardiovascular disease, with more of an increase seen during heat waves, according to research published in the September issue of Circulation: Cardiovascular Quality and Outcomes.

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A 5 Percent Reduction in BMI Could Alter U.S. Obesity Course

WEDNESDAY, Sept. 19 (HealthDay News) -- Obesity trends for 2030 could see considerable improvement if there was a 5 percent reduction in average body mass index for all adults by state, according to a report published online Sept. 18 by the Trust for America's Health (TFAH) and the Robert Wood Johnson Foundation (RWJF).

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Adipose Tissue Distribution Aids Diabetes Risk Determination

TUESDAY, Sept. 18 (HealthDay News) -- Obese adults with dysfunctional adiposity (excess visceral body fat distribution and insulin resistance) are more likely to develop type 2 diabetes than obese adults with general adiposity, according to a study published in the Sept. 19 issue of the Journal of the American Medical Association, a theme issue on obesity.

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Biomarkers Identified in Head and Neck Cancers

TUESDAY, Sept. 18 (HealthDay News) -- In patients with head and neck cancer, human papillomavirus (HPV) infection predicts survival when determined by viral load and viral gene expression rather than the presence of viral DNA or expression of the p16 tumor suppressor gene, according to two studies published online Sept. 18 in Cancer Research.

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Premature Death Rate Higher in People Who Self-Harm

TUESDAY, Sept. 18 (HealthDay News) -- People who self-harm have over three-fold higher rates of premature death, from both natural and external causes, according to a study published online Sept. 18 in The Lancet.

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L-Carnitine Does Not Reduce Cancer-Related Fatigue

TUESDAY, Sept. 18 (HealthDay News) -- Patients with invasive malignancies who take L-carnitine supplements do not experience a reduction in fatigue, pain, or depression, according to research published online Sept. 17 in the Journal of Clinical Oncology.

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VTE Risk Varies by Hormone Therapy Formulation

TUESDAY, Sept. 18 (HealthDay News) -- The risk of venous thromboembolism (VTE) in postmenopausal women differs considerably according to the formulation of hormone therapy (HT) used, with the highest VTE risk seen in users of oral estrogen-progestin HT containing medroxyprogesterone acetate, according to research published online Sept. 10 in the Journal of Thrombosis and Haemostasis.

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Resuming Warfarin After GI Bleed Cuts Mortality

TUESDAY, Sept. 18 (HealthDay News) -- In the 90 days following a gastrointestinal tract bleeding (GIB) event, patients who do not resume warfarin therapy experience an increased rate of thrombosis and death, according to research published online Sept. 17 in the Archives of Internal Medicine.

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Gout Is Primary Indication in About 0.2 Percent of ER Visits

TUESDAY, Sept. 18 (HealthDay News) -- Gout is the primary indication in about 0.2 percent of emergency department visits annually, according to a study published online Sept. 4 in Arthritis Care & Research.

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Cognitive Ability, Motivation Tied in Addictive Behavior

TUESDAY, Sept. 18 (HealthDay News) -- High cognitive functioning enhances one's readiness to change addictive behavior, according to a study published in the September issue of Alcoholism: Clinical & Experimental Research.

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Hip Circumference Inversely Tied to Diabetes Risk

TUESDAY, Sept. 18 (HealthDay News) -- There is an inverse relationship between hip circumference and risk of type 2 diabetes mellitus (T2DM), according to a meta-analysis published online Sept. 3 in Obesity Reviews.

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No Increased Cancer Risk With Herpes Zoster Infection

MONDAY, Sept. 17 (HealthDay News) -- There is no increased risk of cancer among patients with newly diagnosed herpes zoster infection, according to a study published online Sept. 17 in CMAJ, the journal of the Canadian Medical Association.

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Cancer Incidence and Mortality Declining for Hispanics

MONDAY, Sept. 17 (HealthDay News) -- Cancer incidence and death rates seem to be declining for Hispanics, but screening use is lower than for non-Hispanic whites, according to two studies published online Sept. 17 in CA: A Cancer Journal for Clinicians.

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Ethnic Variation Seen in Level of Pancreatic Triglycerides

MONDAY, Sept. 17 (HealthDay News) -- There is considerable ethnic variation in the levels of pancreatic triglycerides (TGs) and in β-cell dysfunction, according to research published online Sept. 11 in Diabetes Care.

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Nicotine Replacement Doesn't Increase Cardio Risk After ACS

MONDAY, Sept. 17 (HealthDay News) -- Use of nicotine replacement therapy (NRT) does not increase the risk of adverse cardiovascular events in the first year following acute coronary syndromes (ACS), according to research published in the Oct. 1 issue of The American Journal of Cardiology.

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Study Looks at Pain Processing Abnormalities in Knee OA

MONDAY, Sept. 17 (HealthDay News) -- For patients with knee osteoarthritis (K-OA), the lack of correlation between clinical pain and radiographic evidence of disease severity may be due to central sensitization, according to a study published online Sept. 7 in Arthritis & Rheumatism.

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Health Ambiguity Linked to Depression in Stroke Survivors

MONDAY, Sept. 17 (HealthDay News) -- Health ambiguity, or uncertainty about the outcome of illness, is significantly associated with depression in survivors of first stroke, and this association is stronger for men than women, according to research published online Sept. 14 in the Archives of Physical Medicine and Rehabilitation.

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Mechanism of Smoking-Induced Insulin Resistance Elucidated

MONDAY, Sept. 17 (HealthDay News) -- Smoking-induced insulin resistance, which improves with smoking cessation, may be due to activation of mammalian target of rapamycin (mTOR), according to a study published online Sept. 10 in Diabetes.

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Considerable Out-of-Pocket Costs in Last Few Years of Life

MONDAY, Sept. 17 (HealthDay News) -- Out-of-pocket health care expenditures can put a significant financial burden on elderly Medicare beneficiaries in their last five years of life, according to a study published online Sept. 4 in the Journal of General Internal Medicine.

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Lung Transplant for CF Less Likely for Medicaid Recipients

FRIDAY, Sept. 14 (HealthDay News) -- For adults with cystic fibrosis (CF), the likelihood of not being accepted for lung transplantation is higher for those with low socioeconomic status, as indicated by Medicaid status, according to a study published online Sept. 13 in the American Journal of Respiratory and Critical Care Medicine.

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Thyroid-Stimulating Hormone Up Over Time in Oldest Old

FRIDAY, Sept. 14 (HealthDay News) -- For the oldest old, increases in thyroid-stimulating hormone (TSH) occur over time but do not correlate with mortality, according to a study published online Aug. 9 in the Journal of Clinical Endocrinology & Metabolism.

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Obstructive Sleep Apnea Ups Cardio Risk in the Elderly

FRIDAY, Sept. 14 (HealthDay News) -- In the elderly, untreated severe obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular death, and adequate treatment with continuous positive airway pressure (CPAP) may reduce this risk, according to research published online Sept. 13 in the American Journal of Respiratory and Critical Care Medicine.

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Higher Mortality Risk With Preoperative Hyponatremia

FRIDAY, Sept. 14 (HealthDay News) -- Patients with preoperative hyponatremia have a higher risk of 30-day mortality and morbidity, including coronary events, surgical site wound infections, and pneumonia, according to research published online Sept. 10 in the Archives of Internal Medicine.

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Risk of Car Accidents Up With Antidepressant Use

FRIDAY, Sept. 14 (HealthDay News) -- There is an increased risk of motor vehicle accidents (MVAs) for patients taking antidepressants, benzodiazepines, or Z-drugs, according to a study published online Sept. 13 in the British Journal of Clinical Pharmacology.

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Job Strain Ups Risk of Coronary Heart Disease

FRIDAY, Sept. 14 (HealthDay News) -- Job strain is associated with an increase in the risk of coronary heart disease, according to a meta-analysis published online Sept. 14 in The Lancet.

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Disability for 15 Percent of Patients After Minor Stroke, TIA

FRIDAY, Sept. 14 (HealthDay News) -- Approximately 15 percent of patients exhibit some disability 90 days after a minor stroke or transient ischemic attack (TIA), and more than 50 percent of patients who have a recurrent event experience disability, according to a study published online Sept. 13 in Stroke.

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'Choosing Wisely' Suggestions Should Improve Kidney Care

FRIDAY, Sept. 14 (HealthDay News) -- The American Society of Nephrology (ASN) Quality and Patient Safety (QPS) Task Force has developed a set of five recommendations to improve care for patients with kidney disease, according to an article published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

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Meta-Analysis: Acupuncture Reasonable Chronic Pain Option

THURSDAY, Sept. 13 (HealthDay News) -- Acupuncture is an effective treatment for chronic pain conditions, including back and neck pain, osteoarthritis, and chronic headache, with pain relief superior to both no-acupuncture controls and sham-acupuncture groups, according to the results of a systematic review and meta-analysis published online Sept. 10 in the Archives of Internal Medicine.

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Advertising Changes After Drug Switch to Over-the-Counter

THURSDAY, Sept. 13 (HealthDay News) -- When a drug switches from prescription-only to over-the-counter (OTC) there is a shift in the direct-to-consumer advertising (DTCA), with less presentation of potential harms and frequent omission of identification by generic names, according to a research letter published online Sept. 11 in the Journal of the American Medical Association.

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European Review: Benefits of Mammograms Outweigh Harms

THURSDAY, Sept. 13 (HealthDay News) -- For women in Europe, mammographic screening is associated with a reduction in breast cancer mortality that is greater than the potential harms of over-diagnosis and false-positive screening results (FPRs), according to a study published in the September issue of the Journal of Medical Screening.

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Diabetes Outcome Better for Patients With Empathetic Docs

THURSDAY, Sept. 13 (HealthDay News) -- Physician empathy, as measured by a validated scale, correlates with clinical outcome for patients with diabetes, with better outcome for those with doctors with high empathy, according to a study published in the September issue of Academic Medicine.

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Rare Cancer Syndrome Linked to Lower Diabetes Risk

WEDNESDAY, Sept. 12 (HealthDay News) -- People with Cowden syndrome, with tumor-suppressor phosphatase and tensin homologue (PTEN) mutations that increase their risk of cancer, have enhanced sensitivity to insulin even though they are more likely to be obese, according to a study published in the Sept. 13 issue of the New England Journal of Medicine.

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Considerable Variation Seen for Medicare Cost-Saving Program

WEDNESDAY, Sept. 12 (HealthDay News) -- There is substantial variation in the savings achieved for practice groups involved in the Medicare Physician Group Practice Demonstration (PGPD) program, designed to improve quality and slow cost growth, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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Tranexamic Acid Safe for Wide Spectrum of Trauma Patients

WEDNESDAY, Sept. 12 (HealthDay News) -- Tranexamic acid reduces risk of death and thrombotic events in patients with traumatic bleeding, irrespective of the baseline risk of death, according to a study published online Sept. 11 in BMJ.

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Persistence of Statin Use Linked to Decreased Cancer Risk

WEDNESDAY, Sept. 12 (HealthDay News) -- There is an inverse association between statin persistence and cancer risk, particularly for hematopoietic malignancies, according to a study published in the September issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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SPECT/CT Associated With Improved Survival in Melanoma

TUESDAY, Sept. 11 (HealthDay News) -- For patients with clinically lymph node-negative melanoma, the use of single-photon emission computed tomography/computed tomography (SPECT/CT) to aid sentinel lymph node excision (SLNE) is associated with increased detection of metastatic involvement and improved disease-free survival, compared with standard SLNE, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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No Superior Method of Adjusting Inhaled Steroids in Asthma

TUESDAY, Sept. 11 (HealthDay News) -- For adults with mild-to-moderate asthma controlled with inhaled corticosteroids, adjustment of corticosteroids based on biomarkers (exhaled nitric oxide) or symptoms does not improve the time to treatment failure compared with physician assessment-based adjustment, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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Review: Omega-3s Do Not Reduce Risk of Cardio Events

TUESDAY, Sept. 11 (HealthDay News) -- Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) is not associated with a statistically significant reduction in major cardiovascular end points, according to research published in the Sept. 12 issue of the Journal of the American Medical Association.

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Less Alzheimer's Pathology With Angiotensin Receptor Blocker Use

TUESDAY, Sept. 11 (HealthDay News) -- In autopsy findings, patients treated with angiotensin receptor blockers (ARBs) show less Alzheimer's disease (AD)-related pathology, according to a study published online Sept. 10 in the Archives of Neurology.

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Adding Ketamine to Opioids Doesn't Reduce Cancer Pain

TUESDAY, Sept. 11 (HealthDay News) -- Using subcutaneously administered ketamine in a dose-escalating regimen as an adjunct to opioids and standard co-analgesics does not have any clinical benefit in relieving cancer pain, but it is associated with increased toxicity, according to research published online Sept. 10 in the Journal of Clinical Oncology.

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Safe Dengue Vaccine Deemed Feasible

TUESDAY, Sept. 11 (HealthDay News) -- A safe recombinant, live, attenuated tetravalent dengue vaccine has been deemed possible, according to a study published online Sept. 11 in The Lancet.

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Updated Guidelines Issued for 'Strep' Diagnosis, Treatment

TUESDAY, Sept. 11 (HealthDay News) -- The Infectious Diseases Society of America recommends use of penicillin or amoxicillin as first-line treatment for culture-confirmed cases of Group A streptococcal (GAS) pharyngitis, according to updated clinical practice guidelines published online Sept. 9 in Clinical Infectious Diseases.

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Costs of Neck and Back Conditions Increasing in U.S.

TUESDAY, Sept. 11 (HealthDay News) -- For individuals with back and neck conditions, costs have increased in the last decade, with the main increase due to rising medical specialist costs, according to a study published in the Sept. 1 issue of Spine.

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Acupuncture Activates Neural Responses in Parkinson's

TUESDAY, Sept. 11 (HealthDay News) -- Patients with Parkinson's disease may benefit from acupuncture treatment on acupoint GB34, with improved neural response noted after acupuncture stimulation, according to a study published in the September issue of CNS Neurosciences & Therapeutics.

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Heavy Drinking Linked to Intracerebral Bleed at Young Age

MONDAY, Sept. 10 (HealthDay News) -- Heavy alcohol intake correlates with intracerebral hemorrhage (ICH) at a younger age, according to a study published in the Sept. 11 issue of Neurology.

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Antihypertensive Use in Pregnancy Increasing

MONDAY, Sept. 10 (HealthDay News) -- The prevalence of antihypertensive use in pregnancy is approaching 5 percent and is increasing, according to a study published online Sept. 10 in Hypertension.

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NSAID Use Ups Cardiovascular Risk Up to Five Years Post-MI

MONDAY, Sept. 10 (HealthDay News) -- The increased cardiovascular risk associated with nonsteroidal anti-inflammatory drug (NSAID) use following a first myocardial infarction (MI) persists up to five years, according to a study published online Sept. 10 in Circulation.

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Cancer Survivors Uneasy With Primary Care Doctor Follow-Up

MONDAY, Sept. 10 (HealthDay News) -- Early-stage cancer survivors have concerns about receiving cancer-related follow-up care from primary care physicians, according to a study published in the September/October issue of the Annals of Family Medicine.

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Long-Term Survival High With Living Donor Liver Transplants

MONDAY, Sept. 10 (HealthDay News) -- Patients with acute liver failure (ALF) who receive a living donor liver transplantation (LDLT) in Japan have excellent short- and long-term survival rates, according to a study published in the September issue of Liver Transplantation.

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Drinking Dealcoholized Red Wine Lowers Blood Pressure

MONDAY, Sept. 10 (HealthDay News) -- Drinking dealcoholized red wine, compared with red wine or gin, decreases systolic and diastolic blood pressure, according to a study published online Sept. 6 in Circulation Research.

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Early Prophylactic Tx Beneficial for Hypertrophic Cardiomyopathy

MONDAY, Sept. 10 (HealthDay News) -- Beta blockers (BBs) are effective as an early prophylactic pharmacologic treatment for patients with mild hypertrophic cardiomyopathy (HC) who have exercise-induced left ventricular outflow tract (LVOT) obstruction, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

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Cognitive Deficits for Chemo-Treated Breast Cancer Patients

FRIDAY, Sept. 7 (HealthDay News) -- Breast cancer survivors who were previously treated with chemotherapy experience small cognitive deficits in the domains of verbal ability and visuospatial ability, according to a study published online Aug. 27 in the Journal of Clinical Oncology.

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Antibody Titer Prognostic in Membranous Nephropathy

FRIDAY, Sept. 7 (HealthDay News) -- Two techniques can be used to measure antiphospholipase A2 receptor (aPLA2R) antibody titers in patients with idiopathic membranous nephropathy (iMN), with antibody titers indicative of outcome, according to research published online Sept. 6 in the Journal of the American Society of Nephrology.

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No Gender Effect on PCI Outcome in Acute Coronary Syndrome

FRIDAY, Sept. 7 (HealthDay News) -- There are no significant gender differences in outcomes between men and women undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) for the treatment of acute coronary syndrome (ACS), according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

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Elevated Rheumatoid Factor Ups Risk of Developing RA

FRIDAY, Sept. 7 (HealthDay News) -- Individuals in the general population with elevated levels of rheumatoid factor have a significantly increased risk of developing rheumatoid arthritis, according to a study published online Sept. 6 in BMJ.

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Diagnostic Radiation Ups Breast Cancer Risk in BRCA Carriers

FRIDAY, Sept. 7 (HealthDay News) -- For BRCA1/2 mutation carriers, exposure to diagnostic radiation before age 30 correlates with a significantly increased risk of breast cancer, with a dose-response pattern, according to a study published online Sept. 6 in BMJ.

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Good Long-Term Prognosis for Benign IgA Nephropathy

FRIDAY, Sept. 6 (HealthDay News) -- The long-term prognosis for Caucasian patients with immunoglobulin A (IgA) nephropathy with benign presentation (consisting of only minor urinary abnormalities and normal renal function) is excellent, without special treatment, according to research published online Sept. 6 in the Journal of the American Society of Nephrology.

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Neurocognitive Deficits Seen in Survivors of Pediatric Hodgkin's

FRIDAY, Sept. 7 (HealthDay News) -- Adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, according to research published online Sept. 4 in the Journal of Clinical Oncology.

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Antiretrovirals Increasingly Used for HIV in the U.S.

FRIDAY, Sept. 7 (HealthDay News) -- Since 2000, more HIV-infected patients in the United States are receiving antiretroviral treatment, viral load has fallen, and CD4 counts at death have risen, according to a study published in the Sept. 4 issue of the Annals of Internal Medicine.

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Not All Docs/Nurses Want to Be Asked About Hand Hygiene

FRIDAY, Sept. 7 (HealthDay News) -- Although most health care workers (HCWs) appreciate the role of patients in preventing health care-associated infection, a considerable proportion are uncomfortable with patients asking about their hand hygiene, according to a letter published online Sept. 3 in the Archives of Internal Medicine.

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Imaging Device Quantifies Change in Port Wine Stains

FRIDAY, Sept. 7 (HealthDay News) -- A newly developed spatial frequency domain imaging (SFDI) device can be used to quantify biochemical compositional changes in port wine stain (PWS) lesions after laser therapy, according to a study published online Aug. 21 in Lasers in Surgery and Medicine.

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Fructose Consumption Impairs Insulin Sensitivity

FRIDAY, Sept. 7 (HealthDay News) -- High levels of fructose can affect hepatic insulin sensitivity, while even moderate consumption of fructose and sucrose can significantly alter lipid profiles in healthy young men, according to research published online Aug. 28 in Diabetes Care.

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Genetic Counseling Doesn't Affect Pre-Diabetes Behavior

THURSDAY, Sept. 6 (HealthDay News) -- Receiving genetic risk counseling does not significantly alter self-reported motivation or prevention program adherence for overweight individuals at risk for type 2 diabetes, according to a study published online Aug. 28 in Diabetes Care.

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Characteristics of Long-Term Gastric Cancer Survivors ID'd

THURSDAY, Sept. 6 (HealthDay News) -- Patients with gastric and gastroesophageal junction (GEJ) cancer who survive for longer than three years after diagnosis seem to have distinct demographic and pathologic characteristics, compared with those who do not survive, according to research published online Sept. 4 in the Journal of Clinical Oncology.

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Good Prognosis for Metabolically Healthy Obese

THURSDAY, Sept. 6 (HealthDay News) -- Individuals who are metabolically healthy but obese have a better prognosis than metabolically abnormal, obese adults; and for adults with acute coronary syndrome (ACS), mortality follows a U-shaped pattern with increasing body mass index (BMI), according to two studies published online Sept. 4 in the European Heart Journal.

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Score Can Assess One-Year Risk of Serious Infection in RA

THURSDAY, Sept. 6 (HealthDay News) -- A risk score based on rheumatoid arthritis (RA) disease characteristics and comorbidities has been developed and validated for assessing the one-year risk of serious infection, according to research published in the September issue of Arthritis & Rheumatism.

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Prevalence of Diagnostic Errors in the ICU Assessed

THURSDAY, Sept. 6 (HealthDay News) -- Diagnostic errors in the intensive care unit (ICU) are prevalent, with 28 percent of autopsies reporting at least one misdiagnosis, according to a study published online July 21 in BMJ Quality & Safety.

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Prone-Position Breast Radiation Avoids Heart, Lung Exposure

THURSDAY, Sept. 6 (HealthDay News) -- For most women with breast cancer, prone positioning during computed tomography (CT) simulation scans correlates with a reduction in the amount of heart and lung irradiation, according to a research letter published in the Sept. 5 issue of the Journal of the American Medical Association.

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Dynamic Diffuse Optical Tomography Can Diagnose PAD

THURSDAY, Sept. 6 (HealthDay News) -- Dynamic diffuse optical tomography (DDOT), a noninvasive, non-ionizing imaging modality, may be a useful new tool for diagnosing peripheral arterial disease (PAD), even in patients with diabetes, according to a study published in the Sept. 1 issue of Biomedical Optics Express.

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Ginkgo Biloba Extract Does Not Cut Progression to Alzheimer's

THURSDAY, Sept. 6 (HealthDay News) -- For elderly adults with memory complaints, use of standardized ginkgo biloba extract is no better than placebo for reducing the incidence of Alzheimer's disease, according to a study published online Sept. 6 in The Lancet Neurology.

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Maternal Smoking Link to Teen Obesity Mediated by Fat Intake

THURSDAY, Sept. 6 (HealthDay News) -- The increased risk of obesity seen in adolescents who experienced prenatal exposure to maternal cigarette smoking (PEMCS) is associated with enhanced dietary intake of fat, which may be partially mediated by changes in the amygdala, according to research published online Sept. 3 in the Archives of General Psychiatry.

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Simple Eye Tracking Can Identify Neurological Disorders

THURSDAY, Sept. 6 (HealthDay News) -- Neurological disorders such as Parkinson's disease and attention-deficit/hyperactivity disorder (ADHD) can be detected with high accuracy by tracking eye movements while watching television, according to a study published online Aug. 27 in the Journal of Neurology.

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Congenital Disease Linked to Adipocyte Development

THURSDAY, Sept. 6 (HealthDay News) -- Some patients with congenital generalized lipodystrophy (CGL), who lack adipocytes and develop severe insulin resistance, have a defect in adipocyte development that can be partially reversed, according to a study published online Aug. 28 in Diabetes.

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Remodeling Starts Within 48 Hours of Cardiac Injury

THURSDAY, Sept. 6 (HealthDay News) -- After cardiac injury, signs of remodeling are observed as early as 48 hours, and include structural changes and enlargement of the heart, and associated changes in cell populations, according to a study published online Sept. 4 in The American Journal of Pathology.

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Perfluorooctanoic Acid Level Tied to Cardiovascular Disease

WEDNESDAY, Sept. 5 (HealthDay News) -- Levels of perfluorooctanoic acid (PFOA), found in household consumer products, correlate positively with cardiovascular disease (CVD) and peripheral arterial disease (PAD), independently of other variables, according to a study published online Sept. 3 in the Archives of Internal Medicine.

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Alzheimer's, ALS Death Rates Up for Football Players

WEDNESDAY, Sept. 5 (HealthDay News) -- Neurodegenerative mortality is about three times higher among retired National Football League players, with Alzheimer's disease and amyotrophic lateral sclerosis mortality even higher, compared to the general U.S. population, according to a study published online Sept. 5 in Neurology.

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Language Barrier Linked to Poorer Asthma Outcomes

WEDNESDAY, Sept. 5 (HealthDay News) -- For elderly patients with asthma, limited English proficiency correlates with poorer outcomes, according to a study published in the September issue of the Annals of Allergy, Asthma & Immunology.

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Reciprocal Increased Risk of Parkinson's, Prostate Cancer

WEDNESDAY, Sept. 5 (HealthDay News) -- Patients with Parkinson's disease (PD) have a significantly increased risk of prostate cancer and melanoma, which extends to their third-degree relatives, and there is evidence of a reciprocal risk, according to a study published online Sept. 3 in the Archives of Neurology.

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Clopidogrel After MI Less Effective in Diabetes Patients

WEDNESDAY, Sept. 5 (HealthDay News) -- Clopidogrel therapy following a heart attack does less to reduce the risk of death in patients with diabetes than in those without diabetes, according to a study published in the Sept. 5 issue of the Journal of the American Medical Association.

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Hospitals Vary in Resuscitation Times for Cardiac Arrest

WEDNESDAY, Sept. 5 (HealthDay News) -- For patients with in-hospital cardiac arrest, the duration of resuscitation attempts varies between hospitals, with increased duration of resuscitation linked to improved survival, according to a study published online Sept. 5 in The Lancet.

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Combat Stress Affects Soldiers' Cognitive Function

WEDNESDAY, Sept. 5 (HealthDay News) -- Combat stress has adverse effects on the mesofrontal circuit of the brain that are partially reversible, according to research published online Sept. 3 in the Proceedings of the National Academy of Sciences.

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Anthracycline, Trastuzumab for Breast CA Up Heart Failure Risk

WEDNESDAY, Sept. 5 (HealthDay News) -- For women with incident, invasive breast cancer, treatment with anthracycline and trastuzumab is associated with an increased risk of heart failure and/or cardiomyopathy, compared to having no chemotherapy, according to a study published in the Sept. 5 issue of the Journal of the National Cancer Institute.

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Over Half of U.S. Adults With HTN Do Not Have It Under Control

TUESDAY, Sept. 4 (HealthDay News) -- Of U.S. adults with hypertension, more than half have uncontrolled hypertension, yet the majority report having a usual source of care and health insurance, according to a study published in the Sept. 4 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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No Increased Risk of Cancer With Biologics in Rheumatoid Arthritis

TUESDAY, Sept. 4 (HealthDay News) -- For patients with rheumatoid arthritis (RA), the use of biologic response modifiers (BRMs) for at least six months is not associated with an increased risk of malignancy compared with placebo or other disease-modifying antirheumatic drugs (DMARDs), according to a study published in the Sept. 5 issue of the Journal of the American Medical Association.

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Unrecognized MI Prevalent in Older Adults, Ups Mortality

TUESDAY, Sept. 4 (HealthDay News) -- For older patients, the prevalence of unrecognized myocardial infarction (UMI), as assessed by cardiac magnetic resonance (CMR) imaging, is higher than that of recognized myocardial infarction (RMI) and correlates with increased mortality, according to a study published in the Sept. 5 issue of the Journal of the American Medical Association.

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Vitamin D Repletion Offers No Short-Term Benefit in Lipids

TUESDAY, Sept. 4 (HealthDay News) -- For vitamin D deficient adults, repletion of vitamin D is not associated with short-term improvement in the lipid profile, according to a study published online Sept. 4 in Arteriosclerosis, Thrombosis, and Vascular Biology.

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Vascular Stiffness Precursor to Hypertension, Not Result

TUESDAY, Sept. 4 (HealthDay News) -- Measures showing higher aortic stiffness and pressure pulsatility are precursors to, not a result of, incident hypertension, according to a study published in the Sept. 5 issue of the Journal of the American Medical Association.

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Addition of Tiotropium Effective in Poorly Controlled Asthma

TUESDAY, Sept. 4 (HealthDay News) -- For patients with poorly controlled asthma, the addition of tiotropium to standard therapy is beneficial, according to a study published online Sept. 3 in the New England Journal of Medicine to coincide with presentation at the annual meeting of the European Respiratory Society, held from Sept. 1 to 5 in Vienna.

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Organic Food Does Not Seem to Be Nutritionally Superior

TUESDAY, Sept. 4 (HealthDay News) -- Based on the published literature, there is a lack of evidence for the health benefits of organic food, according to a review published in the Sept. 4 issue of the Annals of Internal Medicine.

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Plasma Glucose Tied to Atrophy in Hippocampus, Amygdala

TUESDAY, Sept. 4 (HealthDay News) -- For cognitively healthy individuals without type 2 diabetes, high plasma levels within the normal range are associated with atrophy in the hippocampus and amygdala, according to a study published in the Sept. 4 issue of Neurology.

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Stressful Lifestyle, Type A Behavior Linked to Stroke

MONDAY, Sept. 3 (HealthDay News) -- Stressful habits and type A behavior correlate with an increased risk of stroke, according to a study published online Aug. 27 in the Journal of Neurology, Neurosurgery & Psychiatry.

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