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Subclinical Hyperthyroidism Tied to Coronary Heart Disease

And, levothyroxine linked to fewer ischemic heart disease events in younger hypothyroidism patients

TUESDAY, April 24 (HealthDay News) -- Subclinical hyperthyroidism is associated with increased risk of coronary heart disease (CHD) morbidity and mortality; and treatment with levothyroxine for subclinical hypothyroidism is associated with fewer ischemic heart disease (IHD) events in patients aged 40 to 70 years, according to two studies published online April 23 in the Archives of Internal Medicine.

To investigate the association between subclinical hyperthyroidism and the risks of total and CHD mortality, CHD events, and atrial fibrillation, Tinh-Hai Collet, M.D., from the University of Lausanne in Switzerland, and colleagues reviewed data from 10 cohorts involving 52,674 participants, 2,188 of whom had subclinical hyperthyroidism. The researchers found that subclinical hyperthyroidism correlated with an increased risk of total mortality (hazard ratio [HR], 1.24; 95 percent confidence interval [CI], 1.06 to 1.46), CHD mortality (HR, 1.29; 95 percent CI, 1.02 to 1.62), CHD events (HR, 1.21; 95 percent CI, 0.99 to 1.46), and atrial fibrillation (HR, 1.68; 95 percent CI, 1.16 to 2.43). The associations did not differ by age, gender, or preexisting cardiovascular disease, and remained after further adjustment for cardiovascular risk factors.

Salman Razvi, M.D., from Newcastle University in the United Kingdom, and colleagues investigated whether treatment of subclinical hypothyroidism with levothyroxine was associated with IHD morbidity and mortality in 3,093 younger (aged 40 to 70 years) and 1,642 older (older than 70) individuals. There were 68 incidents in 1,634 younger treated individuals versus 97 events in 1,459 untreated individuals (4.2 versus 6.6 percent; adjusted HR, 0.61; 95 percent CI, 0.39 to 0.95). In older individuals, there were 104 events in 819 treated patients versus 88 events in 823 untreated patients (12.7 versus 10.7 percent; adjusted HR, 0.99; 95 percent CI, 0.59 to 1.33).

"Treatment of subclinical hypothyroidism with levothyroxine was associated with fewer IHD events in younger individuals, but this was not evident in older people," Razvi and colleagues conclude.

One author from the second study disclosed financial ties to Merck Serono, which manufactures levothyroxine.

Abstract - Collet
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Abstract - Razvi
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