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Lifetime Excess Weight Linked to Subclinical Myocardial Injury

People with BMI trajectories of stable overweight or obesity have elevated levels of cardiac troponin I, a marker of subclinical myocardial injury

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WEDNESDAY, Oct. 27, 2021 (HealthDay News) -- Long-standing obesity has a detrimental effect on cardiovascular health, according to a study published online Oct. 19 in the Journal of Internal Medicine.

Magnus Nakrem Lyngbakken, M.D., Ph.D., from University of Oslo in Norway, and colleagues analyzed cardiac troponin I (cTnI) with a high-sensitivity assay in 9,739 participants to determine whether lifetime excess weight history is associated with increased concentrations of cTnI over time. Patients were followed across four visits (1984 to 1986, 1995 to 1997, 2006 to 2008, and 2017 to 2019).

The researchers found three clusters of body mass index (BMI) trajectories from visit 1 to 4: stable normal weight, stable overweight, and stable obesity. Participants in stable overweight and stable obesity were at an increased risk for elevated concentrations of cTnI at visit 4 (odds ratios, 1.27 and 1.70, respectively). Participants with stable obesity had 22 percent higher concentrations of cTnI than participants with stable normal weight. Results were not influenced by dysregulated glucose metabolism or abdominal obesity.

"We demonstrate that long-standing obesity is injurious to cardiac health even before symptoms occur," Lyngbakken said in a statement. "This further underlines the importance of weight control in prevention of serious cardiac conditions such as heart failure."

Two authors disclosed financial ties to the pharmaceutical industry.

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