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Marine Omega-3 Fatty Acid, Vitamin D Do Not Cut Risk for A-Fib

Treatment with EPA-DHA or vitamin D3 supplement versus placebo results in no significant difference in incident atrial fibrillation over five years

supplements and heart and cancer risks

THURSDAY, March 18, 2021 (HealthDay News) -- Neither marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), nor vitamin D3 are associated with a reduction in the risk for incident atrial fibrillation (AF), according to a study published in the March 16 issue of the Journal of the American Medical Association.

Christine M. Albert, M.D., M.P.H., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the effects of long-term administration of supplementation with marine omega-3 fatty acids and vitamin D on incident AF in an ancillary 2 x 2 factorial randomized clinical trial involving 25,119 women and men aged 50 years or older. Participants were randomly assigned to EPA-DHA and vitamin D3 (6,272 analyzed); EPA-DHA and placebo (6,270 analyzed); vitamin D3 and placebo (6,281 analyzed); or two placebos (6,296 analyzed).

The researchers found that the primary end point of incident AF occurred in 3.6 percent of the study participants during a median of 5.3 years of treatment and follow-up. Incident AF events occurred in 3.7 and 3.4 percent of participants for the EPA-DHA versus placebo comparison (hazard ratio, 1.09; 95 percent confidence interval, 0.96 to 1.24; P = 0.19). Incident AF events occurred in 3.7 and 3.4 percent of participants for the vitamin D3 versus placebo comparison (hazard ratio, 1.09; 95 percent confidence interval, 0.96 to 1.25; P = 0.19). No evidence was seen for an interaction between the two study agents (hazard ratio, 1.07; 95 percent confidence interval, 0.92 to 1.25; P = 0.39).

"The findings do not support the use of either agent for the primary prevention of incident AF," the authors write.

Pharmavite LLC provided the vitamin D/placebo for the trial, and Quest Diagnostics performed the serum 25-hydroxyvitamin D and plasma phospholipid omega-3 measurements. Pronova BioPharma/BASF donated omega-3 fatty acids.

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