See What HealthDay Can Do For You
Contact Us

Cytomegalovirus Tied to Anemia With Kidney Disease

Patients with higher levels of anti-CMV antibodies have lower number of red blood cells

Cytomegalovirus Tied to Anemia With Kidney Disease

MONDAY, April 14, 2014 (HealthDay News) -- Cytomegalovirus (CMV) may contribute to anemia in patients with chronic kidney disease (CKD), according to a study published online April 10 in the Journal of the American Society of Nephrology.

Lynn M. Butler, Ph.D., from the Karolinska Institute in Stockholm, and colleagues examined kidney biopsies from CKD patients to determine if CMV was present. A mouse model was also examined to identify the effects of murine CMV infection.

The researchers found that kidneys from nine of 13 patients with CKD were positive for CMV protein and that blood levels of CMV immunoglobulin G inversely correlated with red blood cell count in these patients. Systemic murine CMV infection decreased serum erythropoietin levels in mice. Human CMV inhibited hypoxia-induced expression of erythropoietin messenger RNA (mRNA) and protein in erythropoietin-producing cells. This was mediated by CMV early gene expression, because ultraviolet-inactivated virus had no effect. Also, valganciclovir treatment showed that late gene expression was nonessential. Human CMV also inhibited constitutive production of hypoxia inducible factors (HIF)2α mRNA. Nuclear accumulation of HIF2α was inhibited in CMV-infected cells, and the extent of inhibition correlated with CMV protein expression, based on single cell analysis.

"Our findings suggest that renal CMV infection could induce or exacerbate anemia in patients," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.