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Proteinuria Varies in Pediatric Chronic Kidney Disease

Risk factors include glomerular causes of disease and non-white race

MONDAY, March 23 (HealthDay News) -- In children with mild to moderate chronic kidney disease, proteinuria may be associated with disease cause and race, according to study findings published online March 18 in the Clinical Journal of the American Society of Nephrology.

Craig S. Wong, M.D., of the University of New Mexico in Albuquerque, and colleagues conducted a cross-sectional study of 419 pediatric patients.

The researchers found that at any level of glomerular filtration rate, proteinuria was associated with a glomerular cause of chronic kidney disease and non-white race. They also found that proteinuria was less likely to develop in subjects who took renin-angiotensin system antagonists.

"The study design of [the Chronic Kidney Disease in Children cohort study] and the large number of subjects being studied has created an opportunity to further define risk factors for chronic kidney disease progression and to test potentially therapeutic interventions in the years to come," the authors conclude.

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