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Weight Gain Increases Risk of Chronic Kidney Disease

Increased risk observed even in normal weight men

TUESDAY, June 24 (HealthDay News) -- Weight gain over time increases the risk of developing chronic kidney disease, even in men whose weight is in the normal range, according to the results of a study released online May 21 in advance of publication in the Journal of the American Society of Nephrology.

Seungho Ryu, M.D., from Kangbuk Samsung Hospital in Seoul, Korea, and colleagues examined the risk of chronic kidney disease based on changes in weight in 8,792 healthy men with no known risk factors for chronic kidney disease.

During 35,927 person-years of follow-up, there were 427 new cases of chronic kidney disease, the report states. The researchers found that after adjusting for a number of demographic, behavioral and clinical factors, greater weight gain was associated with an increased risk of chronic kidney disease in the normal weight and overweight groups (based on body mass index). Men whose weight varied by only 0.25 kg per year were at lowest risk of chronic kidney disease, while a weight increase of 0.75 kg per year or more predicted chronic kidney disease.

"In summary, increases in body weight are independently associated with an increased risk for chronic kidney disease, even when the body mass index remains within the normal range," Ryu and colleagues conclude.

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