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August 2012 Briefing - Nephrology

Here are what the editors at HealthDay consider to be the most important developments in Nephrology for August 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Even Normal Range Albuminuria Ups Cardiovascular Risk

FRIDAY, Aug. 31 (HealthDay News) -- For patients with type 2 diabetes with normal albumin levels, any degree of albuminuria is associated with an increased risk of cardiovascular events, according to a study published online Aug. 30 in the Journal of the American Society of Nephrology.

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Kidney Stones Increase Risk of Adverse Kidney Outcomes

FRIDAY, Aug. 31 (HealthDay News) -- Kidney stones correlate with an increased risk of adverse kidney outcomes, including end-stage renal disease (ESRD), stage 3b to 5 chronic kidney disease, and sustained doubling of serum creatinine, but increases in absolute rates are small, according to a study published online Aug. 30 in BMJ.

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In Type 2 DM, Proteinuria With SBP <130 Ups CVD Mortality

FRIDAY, Aug. 24 (HealthDay News) -- Patients with type 2 diabetes, proteinuria, and systolic blood pressure (BP) <130 mm Hg are at an increased risk of total and cardiovascular disease (CVD) mortality, suggesting that proteinuria should be taken into account when establishing target systolic BP levels for prevention of fatal CVD events, according to research published online Aug. 14 in the Journal of Internal Medicine.

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Low HDL Cholesterol Ups Risk of Diabetic Nephropathy

WEDNESDAY, Aug. 22 (HealthDay News) -- High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for the development of diabetic nephropathy, but not retinopathy, in patients with type 2 diabetes, according to research published online Aug. 13 in Diabetes Care.

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Men at Greater Lifetime Risk of End-Stage Renal Disease

MONDAY, Aug. 20 (HealthDay News) -- The lifetime risk of developing end-stage renal disease (ESRD) is higher for men than women, at all ages and estimated glomerular filtration rate (eGFR) strata, according to a study published online Aug. 16 in the Journal of the American Society of Nephrology.

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Autoantibodies Predict Severity of IgA Nephropathy

FRIDAY, Aug. 17 (HealthDay News) -- Serum levels of autoantibodies to immunoglobulin G (IgG) and A (IgA) and the modified galactose-deficient IgA1 (Gd-IgA1), seen in IgA nephropathy (IgAN), are strongly associated with disease progression, according to a study published online Aug. 16 in the Journal of the American Society of Nephrology.

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Vancomycin Overprescribed in Bloodstream MSSA Infections

FRIDAY, Aug. 17 (HealthDay News) -- In U.S. dialysis centers treating end-stage renal (ESRD) patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, vancomycin is overprescribed, despite evidence of lower rates of hospitalization and death in cefazolin-treated patients, according to a study published online Aug. 16 in the Journal of the American Society of Nephrology.

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Chronic Kidney Disease Increases Stroke Risk in A-Fib

WEDNESDAY, Aug. 15 (HealthDay News) -- Patients with atrial fibrillation who have chronic kidney disease are at higher risk of stroke or systemic thromboembolism and bleeding, according to a study published in the Aug. 16 issue of the New England Journal of Medicine.

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Biomarker Found to Predict Therapy Benefit in Renal Cancer

WEDNESDAY, Aug. 15 (HealthDay News) -- Pretreatment serum lactate dehydrogenase (LDH) is a predictive biomarker for the survival benefit derived from treatment with the TORC1 inhibitor temsirolimus in patients with renal cell carcinoma (RCC), according to a study published online Aug. 13 in the Journal of Clinical Oncology.

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Kidney Donors, Recipients Have Little Difference in Income

TUESDAY, Aug. 14 (HealthDay News) -- The median income differences between living kidney donors and transplant recipients in the United States are negligible, according to a study published online Aug. 6 in the American Journal of Transplantation.

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Poor Follow-Up of Hospital Tests Often Due to Late Orders

TUESDAY, Aug. 14 (HealthDay News) -- Poor follow-up of test results at or after discharge from the hospital is often due to tests requested on the day of discharge, according to a letter to the editor published online Aug. 13 in the Archives of Internal Medicine.

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Urinary Proteomics Aids Early ID of Diabetic Nephropathy

MONDAY, Aug. 13 (HealthDay News) -- A biomarker classifier in urine can allow early detection of progression to diabetic nephropathy years before onset of macroalbuminuria, according to a study published online Aug. 7 in Diabetes.

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After Bariatric Op, Controlled Diet Can Aid CaOx Supersaturation

THURSDAY, Aug. 9 (HealthDay News) -- After bariatric surgery, following a diet that is normal in calcium, low in oxalate, and moderate in protein, can improve urinary calcium oxalate (CaOx) supersaturation, but not urinary oxalate excretion, in patients with a history of kidney stones, according to a study published in the August issue of Urology.

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Clinicians Can Unintentionally Prompt Nocebo Effect

THURSDAY, Aug. 2 (HealthDay News) -- The nocebo effect, or induction of a symptom perceived as negative by sham treatment and/or the suggestion of negative expectation, may arise from suggestions by doctors and nurses, according to a study published in Deutsches Ärzteblatt International.

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