Genetic Link to Prevalence of Albuminuria Explored

Study of American Indians pinpoints candidate genes

THURSDAY, April 16 (HealthDay News) -- A study of American Indians has pinpointed a number of candidate genes that influence urinary albumin-to-creatinine ratio and may explain why albuminuria has a higher prevalence in this population compared to others, according to research published online April 15 in the Journal of the American Society of Nephrology.

Amy K. Mottl, M.D., of the University of North Carolina at Chapel Hill, and colleagues conducted a study of 3,497 people from 13 American Indian tribes in Arizona, Oklahoma, and North and South Dakota. The researchers analyzed data using two models, one based on age, gender and interaction terms, and the other also controlling for diabetes, blood pressure, body mass index, smoking status and cholesterol levels.

The findings were in line with those of previous studies and should be applicable to other populations as well as American Indians, the researchers note. There were a number of loci with suggested linkage to urinary albumin-to-creatinine ratio, including 1q, 6p, 9q, 18q and 20p, and in the samples from the Dakotas, there were gene-by-diabetes and gene-by-hypertension interactions, the investigators found.

"To our knowledge, this is the first genome scan to investigate gene-by-hypertension and only the second to investigate gene-by-diabetes interaction on albuminuria," the authors write. "Such interaction is critical to the isolation of genetic loci linked to common, complex traits such as albuminuria, as evidenced by our analysis."

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