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New Guidelines Developed for Pediatric Nephrotic Syndrome

Systematic review describes evaluation, treatment and complications

MONDAY, July 27 (HealthDay News) -- New guidelines provide recommendations for the management of pediatric nephrotic syndrome, one of the more common childhood kidney diseases, according to a systematic review in the August issue of Pediatrics.

Debbie S. Gipson, M.D., from the University of North Carolina in Chapel Hill, and colleagues systematically reviewed the published literature to develop guidelines on the evaluation, treatment, and complications in children with primary nephrotic syndrome.

Initial evaluation should include methods such as urinalysis and evaluation of cholesterol levels, the authors note. Treatment should consist of prednisone initially, or other treatments for relapsing disease or steroid-dependent or -independent disease. Control of hypertension and edema are also important, the guidelines state. Complications can include growth complications, dyslipidemia, infections and thromboembolism. The guidelines also provide recommendations for vaccinations and monitoring.

"Pediatric patients and their caregivers require education regarding the complex treatment of this chronic condition, including proper administration of medications, adherence to dietary restrictions, and necessity for medical monitoring," Gipson and colleagues conclude.

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