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Women Face Less Kidney Disease Morbidity and Mortality Than Men

Risk for progression to end-stage renal disease and death appears to be lower in women than men


MONDAY, Dec. 10, 2018 (HealthDay News) -- Women may have a lower risk for chronic kidney disease (CKD) progression and death compared with men, according to a study published online Dec. 3 in the Journal of the American Society of Nephrology.

Ana C. Ricardo, M.D., M.P.H., from the University of Illinois at Chicago, and colleagues prospectively investigated sex differences in CKD progression using data from 3,939 adults (2,161 men; mean age, 58 years; 42 percent black and 13 percent Hispanic) participating in the Chronic Renal Insufficiency Cohort Study.

During 6.9 years of follow-up, the researchers found that 844 individuals developed end-stage renal disease, while 853 died. Compared with men, women had a significantly lower risk for end-stage renal disease, 50 percent estimated glomerular filtration rate (eGFR) decline, progression to CKD stage 5, and mortality in multivariable regression models. The difference in mean unadjusted eGFR slope between women and men was not significant after multivariable adjustment.

"The results of this study suggest that biology and psychosocial factors may be the driver of the sex-related disparity observed in patients with CKD," Ricardo said in a statement.

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