Live Donor Kidney Transport Likely Safe

Post-transplant function appears unaffected by cold ischemia time

THURSDAY, Jan. 27 (HealthDay News) -- Live donor kidneys that are transported for transplant function just as well as do kidneys removed and transplanted on site, according to a study published online Jan. 10 in the American Journal of Transplantation.

Dorry L. Segev, M.D., Ph.D., of Johns Hopkins University in Baltimore, and colleagues reviewed the outcomes of 56 kidney-paired donations (KPD) performed among 30 transplant centers between April 27, 2007, and April 29, 2010, involving transport of the donor kidney. Early graft function was assessed by urine output in the first eight hours, postoperative serum creatinine trend, and incidence of delayed graft function.

The researchers found that the transported kidneys functioned well, making urine and clearing creatinine quickly in most patients. The median cold ischemia time was 7.2 hours, and the donor kidneys traveled an average of 792 miles. Only four patients had early urine output <100 mL/hr. Creatinine nadir, which occurred at a median of three days, was <2.0 mg/dL in all but one patient. Initial urine output was not associated with the cold ischemia time. None of the patients experienced delayed graft function requiring dialysis in the first week postoperatively.

"In conclusion, we provide evidence to suggest that live donor kidney transport is safe and feasible," the authors write. "This study supports the continued practice of live donor kidney transport for the purposes of facilitating KPD."

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