Low-Carb, High-Fat Diet Helps in Alzheimer Mouse Model

Study contradicts view that saturated fat intake is a risk factor for Alzheimer disease

THURSDAY, Oct. 20 (HealthDay News) -- A high-fat, low-carbohydrate diet reduces amyloid-beta in a mouse model of Alzheimer disease, according to a study in the Oct. 17 issue of Nutrition and Metabolism.

Samuel T. Henderson of Accera, Inc. in Broomfield, Colo., and colleagues in Belgium compared mice fed a high-carbohydrate, low-fat standard diet or a high-fat, low-carbohydrate ketogenic diet for 43 days. Mice fed the ketogenic diet had greater weight loss and serum ketone levels compared with the control mice. The ketogenic diet also produced a 25% reduction in amyloid-beta levels. Changes in ketones, body weight and amyloid-beta were not associated with any behavioral changes.

"Here we demonstrate that a diet rich in saturated fats and low in carbohydrates can actually reduce levels of amyloid-beta. Therefore, dietary strategies aimed at reducing amyloid-beta levels should take into account interactions of dietary components and the metabolic outcomes, in particular, levels of carbohydrates, total calories and presence of ketone bodies should be considered," the authors conclude.

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