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Meta-Analysis Links Adiposity to Increased Risk of Meningioma

High versus low levels of physical activity linked to reduction in risk of meningioma

THURSDAY, Sept. 17, 2015 (HealthDay News) -- Adiposity is associated with an increased risk of meningioma but not glioma, according to a meta-analysis published online Sept. 16 in Neurology.

Tobias Niedermaier, M.P.H., from the University of Regensburg in Germany, and colleagues conducted a systematic review and meta-analysis of adiposity and physical activity in relation to meningioma and glioma. Data were included from 12 eligible studies of body mass index (BMI) and six studies of physical activity that included 2,982 meningioma cases and 3,057 glioma cases.

The researchers found that overweight and obesity were associated with an increased risk of meningioma compared with normal weight (summary relative risk [RR] for overweight, 1.21; 95 percent confidence interval [CI], 1.01 to 1.43 and RR for obesity, 1.54; 95 percent CI, 1.32 to 1.79). There was no correlation for overweight or obesity with glioma (RR for overweight, 1.06; 95 percent CI, 0.94 to 1.2 and RR for obesity, 1.11; 95 percent CI, 0.98 to 1.27). In dose-response meta-analyses, there was a significant positive correlation for BMI with meningioma but not glioma. High versus low physical activity levels correlated with inverse associations for meningioma (RR, 0.73; 95 percent CI, 0.61 to 0.88) and glioma (RR, 0.86; 95 percent CI, 0.76 to 0.97). Based on prospective studies, the correlation between physical activity and glioma was no longer statistically significant (RR, 0.91; 95 percent CI, 0.77 to 1.07).

"Adiposity is related to enhanced risk for meningioma but is unassociated with risk for glioma," the authors write.

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