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Gene Variation Linked to Cerebral Venous Thrombosis

Factor XII C46T gene polymorphism independently and significantly increases the risk

TUESDAY, Jan. 8 (HealthDay News) -- Patients who carry the TT genotype of the functional factor XII C46T gene polymorphism may be at increased risk of developing cerebral venous thrombosis, according to research published in the Jan. 8 issue of Neurology.

K.H. Reuner, M.D., of Stadtisches Klinikum Karlsruhe, Germany, and colleagues assessed the FXII C46T genotype in 78 cerebral venous thrombosis patients and 201 healthy controls.

The researchers found that the cerebral venous thrombosis patients were significantly more likely than healthy controls to carry the TT genotype of the FXII C46T polymorphism (16.7 percent versus 5.5 percent), and that the TT genotype was independently and significantly associated with cerebral venous thrombosis (adjusted odds ratio 4.57).

"Our findings strongly indicate a role of the FXII 46 TT genotype in cerebral venous thrombosis," the authors conclude. "If confirmed by a second independent study, our data should promote the inclusion of the FXII C46T gene polymorphism into the routine diagnostic work-up of cerebral venous thrombosis."

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