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ICAD: Gene Reduces Functional Connectivity

Carriers have reduced connectivity between hippocampus and posterior cingulate cortex

WEDNESDAY, July 30 (HealthDay News) -- In neurologically normal, middle-aged apolipoprotein E-4 (APOE-4) carriers, functional connectivity between the hippocampus and the posterior cingulate cortex is significantly reduced from that of non-APOE-4 carriers, according to research presented this week at the Alzheimer's Association International Conference on Alzheimer's Disease in Chicago.

Zhilin Wu, Ph.D., of the Medical College of Wisconsin in Milwaukee and colleagues studied 28 subjects ages 45 to 65, including 12 who carried APOE-4.

The researchers found that APOE-4 carriers had a significantly lower mean level of functional connectivity between the hippocampus and the posterior cingulate cortex at resting state than non-APOE-4 carriers (-0.17 versus 0.47).

According to the researchers, this study builds on previous studies showing a cerebral glucose metabolic decline in the posterior cingulate cortex and reduced hippocampus activation in APOE-4 carriers. "This result suggests that the reduction in the functional connectivity at resting-state of the APOE-4 carriers is associated with the risk of AD (Alzheimer's disease)," the authors conclude.

Abstract

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