WEDNESDAY, Jan. 7 (HealthDay News) -- Smoking and family history of aneurysmal subarachnoid hemorrhage are independently associated with an increased risk of aneurysmal subarachnoid hemorrhage, researchers report in the Jan. 6 issue of Neurology.
Daniel Woo, M.D., of the University of Cincinnati College of Medicine, and colleagues studied 339 cases of aneurysmal subarachnoid hemorrhage and 1,016 matched controls.
Compared to current non-smokers with no family history of aneurysmal subarachnoid hemorrhage, the researchers found that current non-smokers with a family history of aneurysmal subarachnoid hemorrhage, current smokers with no family history of aneurysmal subarachnoid hemorrhage, and current smokers with a family history of aneurysmal subarachnoid hemorrhage had a steadily increased risk of aneurysmal subarachnoid hemorrhage (odds ratios, 2.5, 3.1 and 6.4, respectively).
"Evidence of a gene-environment interaction with smoking exists for aneurysmal subarachnoid hemorrhage," the authors conclude. "This finding is important to counseling family members and for screening of intracranial aneurysm as well as the design and interpretation of genetic epidemiology of intracranial aneurysm studies."
Abstract
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