See What HealthDay Can Do For You
Contact Us

Combination of Stroke, Genetics Linked to Dementia

Apolipoprotein E 4 allele increases dementia risk

THURSDAY, Dec. 27 (HealthDay News) -- Elderly individuals who have both the apolipoprotein E (APOE) 4 allele and have had a stroke are at higher risk of developing dementia, according to the results of a study published in the Jan. 1 issue of Neurology.

Yaping Jin, M.D., Ph.D., from London Health Sciences Centre and University of Western Ontario in Canada, and colleagues assessed the combined effect of having the APOE 4 allele and stroke on the risk of dementia in 740 elderly individuals.

After a median follow-up of 4.6 years, the researchers found that the incidence of dementia was much higher in individuals with both the APOE 4 allele and stroke than in individuals with neither (8.4 versus 4.3 per 100 person-years). Compared to individuals without stroke or APOE 4 allele, the adjusted hazard ratios of incident dementia were 1.33 for stroke alone, 2.06 for APOE 4 alone, and 2.57 for both.

"The joint presence of stroke and APOE 4 was associated with a greater risk of dementia compared with absence of these two factors," Jin and colleagues conclude. "The effect of stroke on dementia does not seem to be modified by APOE 4."

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing
undefined
undefinedundefined