Genetic Link Seen in Ischemic, Atherothrombotic Strokes

SNPs on chromosome 12p13 near NINJ2 associated with increased risk of strokes

WEDNESDAY, April 15 (HealthDay News) -- A locus on chromosome 12p13 may be linked to an increased risk of stroke, according to research published online April 15 in the New England Journal of Medicine.

M. Arfan Ikram, M.D., of the Erasmus MC University Medical Center in Rotterdam, the Netherlands, and colleagues analyzed data from four cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, which included 19,602 white subjects. The investigators tested the strongest markers in three replication samples featuring black subjects and Dutch whites.

Two single-nucleotide polymorphisms on chromosome 12p13 near NINJ2 -- which encodes ninjurin2, an adhesion molecule in glia that shows higher expression following nerve injury -- were associated with stroke, the researchers report. For rs11833579, the hazard ratios for total and ischemic stroke were 1.26 and 1.33, respectively. For rs12425791, the hazard ratios were 1.30 and 1.33, respectively. The authors observed replication of rs12425791 in the Dutch sample and one of the samples of black subjects.

"We had a priori considered total stroke, a heterogeneous phenotype, as our primary outcome. However, the stronger association with ischemic and atherothrombotic strokes (as compared with total stroke) and the absence of any association with nonischemic stroke indicate that rs11833579 and rs12425791 were specifically associated with ischemic stroke and, in particular, the atherothrombotic stroke subtype," the authors write.

Two authors disclosed financial arrangements with several pharmaceutical companies.

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