Secretoneurin Promotes Neuroprotection After Stroke
In vivo and in vitro, the neuropeptide also enhances neurogenesis and angiogensis
MONDAY, Dec. 17 (HealthDay News) -- Secretoneurin, a neuropeptide derived from secretogranin II, may promote neuroprotection and neuronal plasticity after a stroke, according to a report published online Dec. 13 in the Journal of Clinical Investigation.
Woei-Cherng Shyu, M.D., of the China Medical University and Hospital in Taichung, China, and colleagues studied the effects of secretoneurin in a rat model of stroke and in human ischemic brain tissue.
The researchers found that secretoneurin rescued primary cortical cell cultures from oxygen/glucose deprivation, induced expression of the antiapoptotic proteins Bcl-2 and Bcl-xL through the Jak2/Stat3 pathway, and inhibited apoptosis by blocking caspase-3 activation.
"Both in vitro and in vivo, secretoneurin not only promoted neuroprotection, but also enhanced neurogenesis and angiogenesis," the authors conclude. "Our results demonstrate that secretoneurin acts directly on neurons after hypoxia and ischemic insult to further their survival by activating the Jak2/Stat3 pathway."