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High Risk of Recurrent Stroke with Moyamoya Disease

Surgery may benefit those detected early

FRIDAY, May 12 (HealthDay News) -- Patients presenting with angiographic moyamoya phenomenon where lenticulostriate arteries hypertrophy to bypass a cerebral artery occlusion have an increased chance for stroke, according to a report published online April 27 in the journal Stroke.

To describe clinical features of the disease, Colin P. Derdeyn, M.D., and colleagues from Washington University School of Medicine in St. Louis, reviewed angiographic records from 34 patients with prominent lenticulostriate moyamoya collaterals collected at their institution between 1996 and 2005. A mean follow-up of 5.1 years was included in 31 living patients.

The investigators found that the median age of patients was 42. Twenty-five of the patients were women, and the majority first presented with ischemia. Eighty-two percent of patients with bilateral involvement presenting with ischemia had a stroke within five years. Those treated surgically had a five-year risk for stroke or death of 17 percent.

"Moyamoya phenomenon in North American adults is associated with a high risk of recurrent stroke, particularly those with bilateral involvement and ischemic symptoms," the authors write. "These data suggest a potential benefit with surgery if diagnosis could be made earlier."

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