See What HealthDay Can Do For You
Contact Us

Blockage of Cellular Pathway Associated with Parkinson's

Proteins that unblock pathway reverse neuronal loss

THURSDAY, June 22 (HealthDay News) -- Researchers have demonstrated that blocking a cellular pathway can cause neuronal death, and they have identified proteins that could reverse the neuronal loss in three different animal models of Parkinson disease, according to a report published online June 22 in Science.

Susan Lindquist, Ph.D., of the Whitehead Institute for Biomedical Research in Cambridge, Mass., and colleagues investigated the function of misfolded alpha-synuclein (αSyn) protein associated with the pathogenesis of Parkinson disease.

In yeast, accumulated αSyn protein blocked cellular transport between the endoplasmic reticulum and the Golgi apparatus. A genetic screen in yeast identified proteins that could unblock this transport. Expression of one of these proteins -- Rab1 -- in Drosophila, Caenorhabditis elegans and cultured rat midbrain neurons reversed the αSyn-induced death of dopamine-producing neurons, according to the study.

"The ability of Rab1 to protect against αSyn-induced neuron loss in three independent animal models is strong evidence for a link between αSyn and endoplasmic reticulum-Golgi trafficking," Lindquist and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.