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Marker in Spinal Fluid Predicts Course in Parkinson's Disease

High levels of α-synuclein associated with faster cognitive decline in Parkinson's disease

Marker in Spinal Fluid Predicts Course in Parkinson's Disease

THURSDAY, March 20, 2014 (HealthDay News) -- Levels of α-synuclein in cerebrospinal fluid (CSF) might predict cognitive decline in patients with Parkinson's disease, according to research published online March 13 in the The American Journal of Pathology.

Tessandra Stewart, Ph.D., of the University of Washington in Seattle, and colleagues examined data from more than 300 unmedicated patients who were participating in a randomized trial for the treatment of Parkinson's disease. The authors sought to assess the association between levels of α-synuclein, a CSF biomarker for Parkinson's disease, and motor or cognitive function.

The researchers found that, despite decreasing levels of α-synuclein with levodopa therapy, α-synuclein levels did not correlate with motor symptoms. Longitudinal tracking showed that lower levels of α-synuclein predicted increased preservation of cognitive function by several measures, including Selective Reminding Test total recall α-synuclein x time interaction effect coefficient, −0.12 (P = 0.037); delayed recall, −0.05 (P = 0.002); and New Dot Test, −0.03 (P = 0.002).

"Thus, α-synuclein, although not clinically useful for motor progression, might predict cognitive decline, and future longitudinal studies should include this outcome for further validation," the authors write.

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