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Reduced Circadian Rhythmicity Tied to Increase in Parkinson Disease

Risk for developing PD about threefold higher in lowest quartile of amplitude, mesor, robustness

FRIDAY, June 19, 2020 (HealthDay News) -- Reduced circadian rhythmicity is associated with an increased risk for incident Parkinson disease (PD), according to a study published online June 15 in JAMA Neurology.

Yue Leng, M.D., Ph.D., from the University of California in San Francisco, and colleagues examined the association between rest-activity rhythm and risk for incident PD using data for 2,930 men without PD at baseline who were included in the ancillary sleep study of the longitudinal cohort Osteoporotic Fractures in Men Study.

The researchers found that 2.7 percent of the men developed PD during 11 years of follow-up. The risk for PD increased with decreasing circadian amplitude (strength of the rhythm), mesor (mean level of activity), or robustness (how closely activity follows a cosine 24-hour pattern) after accounting for all covariates (odds ratios per 1-standard deviation decrease, 1.77, 1.64, and 1.54, respectively). The risk for developing PD was about threefold higher for those in the lowest versus the highest quartile of amplitude, mesor, or robustness (odds ratios, 3.11, 3.04, and 2.65, respectively). After further adjustment for nighttime sleep disturbances and duration in the lowest versus the highest quartile, the association persisted (odds ratios, 3.56, 3.24, and 3.34 for amplitude, mesor, and robustness, respectively).

"Markers of circadian rhythmicity might be valuable as a prodromal feature to help with the early detection of PD," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

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