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Pregabalin Relieves Spinal Cord Injury Pain

Drug also improves overall well-being

WEDNESDAY, Nov. 29 (HealthDay News) -- Pregabalin relieves pain better than a placebo in patients with spinal cord injury and improves overall well-being, researchers report in the Nov. 28 issue of Neurology.

Philip J. Siddall, M.B.B.S., Ph.D., from the University of Sydney in Australia, and colleagues randomly assigned 137 patients with central neuropathic pain due to spinal cord injury to either placebo or 150 to 600 mg/day of pregabalin for 12 weeks.

The researchers found that by the end of the study, significantly fewer patients in the pregabalin group reported severe pain (15.9 versus 43.3 percent) and more than one-third of pregabalin patients reported mild or no pain compared with 10.5 percent of placebo patients. Pain relief was observed after as little as one week, the report indicates. Pregabalin also significantly improved anxiety and disturbed sleep, and significantly more patients reported global improvement.

"Pregabalin 150 to 600 mg/day was effective in relieving central neuropathic pain, improving sleep, anxiety, and overall patient status in patients with spinal cord injury," Siddall and colleagues conclude.

The study was funded by Pfizer Global Pharmaceuticals.

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