ART Conception Tied to Increased Odds of Maternal Morbidity

For singleton pregnancies, increased odds of severe maternal morbidity, although rate down since 2008

fetus in the womb

THURSDAY, Dec. 17, 2015 (HealthDay News) -- For singleton pregnancies, conception with assisted reproductive technology (ART) is associated with increased risk of severe maternal morbidity, according to a study published in the January issue of Obstetrics & Gynecology.

Angela S. Martin, M.D., from Emory University in Atlanta, and colleagues examined trends in severe maternal morbidity from 2008 to 2012 in delivery and postpartum hospitalizations among ART- and non-ART-conceived pregnancies.

Overall, 1.5 percent of the 1,016,618 deliveries were identified as pregnancies conceived with ART. The researchers found that the most common severe morbidity indicator for ART and non-ART pregnancies was blood transfusion. Per 10,000 singleton deliveries there were 273 ART deliveries or postpartum hospitalizations with severe maternal morbidity, compared with 126 for non-ART (P < 0.001). From 2008 to 2012, the rate of severe morbidity decreased from 369 to 219 per 10,000 deliveries for ART singleton deliveries (P = 0.025). For ART versus non-ART singletons the odds of severe morbidity were increased (adjusted odds ratio, 1.84). No significant difference was seen in the rate of severe morbidity between ART and non-ART pregnancies among multiple gestations (P = 0.089).

"Singleton pregnancies conceived with ART are at increased risk for severe maternal morbidity; however, the rate has been decreasing since 2008," the authors write.

Full Text (subscription or payment may be required)

Physician's Briefing