See What HealthDay Can Do For You
Contact Us

Tailored Chemo More Effective with Amplified Cancer Genes

Anthracycline-based chemotherapy more effective in women with breast cancer and HER-2/neu and TOP2A amplifications

WEDNESDAY, May 10 (HealthDay News) -- Breast cancer patients whose tumors have amplifications of two genes have better relapse-free survival if treated with individually tailored and dose-escalated adjuvant anthracycline-based chemotherapy, according to a report published online May 8 in the Journal of Clinical Oncology.

Jorma Isola, M.D., Ph.D., from Tampere University in Finland, and colleagues retrospectively analyzed stored tissue samples taken from 391 high-risk breast cancer patients for amplification of the HER-2/neu gene. Amplification of the TOP2A gene was also examined in tumors with HER-2/neu amplification. One group of women received nine courses of tailored and dose-escalated anthracycline-based chemotherapy with fluorouracil, epirubicin and cyclophosphamide. Another group received three to four courses of standard anthracycline-based chemotherapy followed by bone marrow-supported high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin.

The investigators found that HER-2/neu was amplified in 32.7 percent of tumors and that TOP2A was co-amplified in 37 percent of these tumors. While HER-2/neu amplification alone was significantly associated with short relapse-free and overall survival, TOP2A co-amplification was associated with better relapse-free survival, specifically for patients treated with nine courses of tailored and dose-escalated anthracycline-based chemotherapy.

"Co-amplification of HER-2/neu and TOP2A may define a subgroup of high-risk breast cancer patients who benefit from individually tailored and dose-escalated adjuvant anthracyclines," the authors conclude.

The study was funded by Amgen Inc., Roche Inc. and the former Pharmacia Inc., now part of Pfizer Inc.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.