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Soy, Isoflavone Intake Has No Effect on Endometrial Cancer Risk

Findings in large study of Japanese women food consumption examining endometrial cancer risk

THURSDAY, June 26, 2014 (HealthDay News) -- There is no association between soy intake and endometrial cancer risk, according to a study published online June 18 in BJOG: An International Journal of Obstetrics & Gynaecology.

S. Budhathoki, from the National Cancer Center in Japan, and colleagues evaluated soy intake measured in a food frequency questionnaire (1995 to 1998) among 49,121 women (aged 45 to 74 years) also participating in a five-year follow-up survey questionnaire.

The researchers found that over an average of 12.1 years of follow up, there were 112 newly diagnosed endometrial cancer cases. There was no association between energy-adjusted intakes of soy food and isoflavone and the risk of endometrial cancer. Per 25 g/day increase in the intake of soy food, the multivariate-adjusted hazard ratio was 1.02 (95 percent CI, 0.94 to 1.10), and the corresponding value for isoflavone intake per 15 mg/day was 1.01 (95 percent CI, 0.84 to 1.22).

"In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk," the authors write.

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