Bisphenol-A Has Detrimental Effects on Oocytes
Increased rates of abnormal oocyte maturation observed in vitro
WEDNESDAY, July 31 (HealthDay News) -- Exposure of oocytes to bisphenol-A (BPA) has detrimental effects on cell growth and increases oocyte degeneration and spontaneous activation, according to a study published online July 30 in Human Reproduction.
Ronit Machtinger, M.D., from Brigham & Women's Hospital and Harvard Medical School in Boston, and colleagues exposed 352 oocytes from 121 patients undergoing fertility treatment to medium containing 0, 20, 200, or 20,000 ng/ml BPA.
The researchers found a significant decline in the percentage of oocytes that progressed to metaphase II with increasing BPA dose. Of the oocytes that did progress, there was a significant reduction in bipolar spindles and aligned chromosomes. Increasing BPA dose was also associated with a significant increase in the percentage of degenerated oocytes and of oocytes that had undergone spontaneous activation.
"Together with prior animal studies, the data support the negative influences of BPA on cell cycle progression, spindle architecture, and chromosome organization during oocyte maturation," Machtinger and colleagues conclude.