Chromosomal Defects Found in Embryos from Young Donors

About 52% of embryos show aneuploidy when eggs are from healthy young donors

MONDAY, Oct. 17 (HealthDay News) -- More than half of the embryos formed from the eggs of healthy young donors show chromosomal abnormalities, according to a study released Monday at the annual meeting of the American Society for Reproductive Medicine in Montreal.

William Kearns, M.D., of the Shady Grove Fertility Reproductive Science Center in Rockville, Md., and colleagues sought to determine the incidence of embryonic aneuploidy in the general population. The researchers investigated 13 couples who used an egg donor due to poor prior outcomes. The couples underwent 14 cycles, producing 159 embryos. The donors' average age was 26.6 years.

Six percent of the embryos did not undergo preimplantation genetic diagnosis due to the poor quality of the blastomere. However, 52% of the remaining embryos were found to be abnormal for at least one of the 10 chromosomes tested.

"These aneuploidy screening data from donor egg cycles provide insight into the presence of aneuploidy in a low-risk population," the authors conclude. Until now, data on chromosomal abnormality rates in embryos have come from infertility patients and people with genetic disorders.

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