In Vitro Maturation Has Same Risks As Other Technologies

Multiple pregnancy, Caesarean delivery and congenital abnormality rates all higher than for natural conception

WEDNESDAY, Oct. 3 (HealthDay News) -- All types of assisted reproductive technology, including in vitro maturation, in vitro fertilization and intracytoplasmic sperm injection carry greater risks of multiple pregnancy, Caesarean delivery and congenital abnormality, and in vitro maturation has a similar risk profile to other methods, according to study findings published in the October issue of Obstetrics & Gynecology.

William M. Buckett, M.D., of McGill University, Royal Victoria Hospital in Montreal, Canada, and colleagues analyzed data from 432 births resulting from 344 pregnancies after assisted reproductive technology, of which 55 were a result of in vitro maturation, 217 resulted from in vitro fertilization, and 160 as a result of intracytoplasmic sperm injection.

The odds ratios across all three technologies were similar for congenital abnormalities, twin and triplet pregnancies, and Caesarean delivery, the report indicates. The babies had similar Apgar scores, cord pH, growth restriction and pregnancy complication rates regardless of method of assisted reproductive technology.

"When assisted reproductive technology is indicated, in vitro maturation offers a reduction in the risks of ovarian stimulation. Based on current data, we have been unable to demonstrate any increased risk of congenital abnormality or perinatal outcome over that already accepted for in vitro fertilization or intracytoplasmic sperm injection," the authors conclude.

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