Infertility Treatment Safe After Borderline Ovarian Tumor

But data is insufficient to assess risk of infertility treatment following more advanced disease

FRIDAY, March 30 (HealthDay News) -- Infertility treatment appears to be a safe option for women who have problems conceiving after conservative surgical treatment of borderline ovarian tumors, according to the results of a small study published in the March issue of Fertility and Sterility. However, the results cannot be extrapolated to patients with later-stage disease.

Philippe Morice, M.D., of the Institut Gustave Roussy in Villejuif, France, and colleagues used a retrospective, multicenter study of 30 patients who underwent conservative surgery for borderline ovarian tumors, which left them with an intact uterus and at least part of one ovary. Twenty patients were initially treated for stage I disease, four for stage II, and four for stage III; two were not identified.

The women subsequently underwent ovarian induction, including five women who were harvesting oocytes prior to more radical surgery due to a relapse. Four of the other 25 patients experienced a subsequent borderline recurrence, three of whom had received an initial cystectomy; all patients are now disease-free. Thirteen of 30 patients became pregnant, 10 among the 25 patients treated for infertility.

"These results suggest that infertility drugs could be used safely in patients who experience infertility after conservative treatment of an early-stage disease that has been carefully observed," the authors write. "In patients with more advanced-stage disease, the number of patients is too limited to draw conclusions regarding the effect of infertility drugs on outcomes."

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