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ESHRE: Hormone Promising for Predicting Menopause Age

Anti-Müllerian hormone test may point to early menopause in young women, aid in family planning

MONDAY, June 28 (HealthDay News) -- Anti-Müllerian hormone (AMH) may be useful in predicting women's age at menopause, according to research presented at the annual meeting of the European Society of Human Reproduction and Embryology, held from June 27 to 30 in Rome.

Fahimeh Ramezani Tehrani, M.D., of the Shahid Beheshti University of Medical Sciences in Tehran, Iran, and colleagues analyzed data from 266 women aged 20 to 49 years. Women underwent AMH assessment three times at roughly three-year intervals.

The researchers found that their model's estimated age at menopause had good agreement with actual menopause age for 63 women in the group who reached menopause during the study. The average difference between predicted age and actual age was about four months. AMH levels that predicted early menopause in women at ages 20, 25, and 30 were 4.1 ng/mL or less, 3.3 ng/mL, and 2.4 ng/mL, respectively, while AMH levels of at least 4.5 ng/mL at the age of 20, 3.8 ng/mL at 25, and 2.9 ng/mL at 30 predicted onset of menopause after age 50.

"The results from our study could enable us to make a more realistic assessment of women's reproductive status many years before they reach menopause. To the best of our knowledge this is the first prediction of age at menopause that has resulted from a population-based cohort study. We believe that our estimates of ages at menopause based on AMH levels are of sufficient validity to guide medical practitioners in their day-to-day practice, so that they can help women with their family planning," Tehrani said in a statement.

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