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Ovarian Conservation Safe in Endometrial Cancer but Use Low

Findings among premenopausal women undergoing hysterectomy

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TUESDAY, Dec. 15, 2015 (HealthDay News) -- Despite the safety of ovarian conservation, the majority of young women with endometrial cancer still undergo oophorectomy, according to a study published in the January issue of Obstetrics & Gynecology.

Jason D. Wright, M.D., from Columbia University in New York City, and colleagues utilized data from the National Cancer Database (1998 to 2012) to identify 15,648 women (<50 years of age) with stage I endometrioid adenocarcinoma of the endometrium who underwent hysterectomy. Women were characterized based on whether they underwent oophorectomy (92.8 percent) or had ovarian conservation (7.2 percent).

The researchers found that the rate of ovarian conservation was relatively stable (6.9 percent in 1998 versus 7.1 percent in 2012; P = 0.91). Younger women, black women, those with low-grade and earlier stage tumors, and women treated at community hospitals more commonly had ovarian conservation. Ovarian conservation was not independently associated with survival (hazard ratio, 0.94; 95 percent confidence interval, 0.65 to 1.37).

"Ovarian conservation does not adversely affect survival for women with early-stage endometrial cancer," the authors write.

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