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APS: Single Exercise Session Improves Metabolic Health

Small study of obese women shows that exercise reverses adverse metabolic effects of overeating

FRIDAY, Sept. 26 (HealthDay News) -- In obese women with insulin sensitivity, even one session of acute exercise can reverse the suppressed fatty acid oxidization caused by overeating and may repartition fatty acid uptake toward intramyocellular triglyceride concentration resynthesis, according to research presented at the American Physiological Society Intersociety Meeting: The Integrative Biology of Exercise V held Sept. 24 to 27 in Hilton Head, S.C.

Andrea Cornford, a Ph.D. candidate at the University of Michigan in Ann Arbor, and colleagues studied five obese women who performed three separate two-day trials: a weight-maintaining diet, a hypercaloric diet including 700 excess calories, and a hypercaloric diet followed by enough exercise to burn the excess calories.

Compared to the weight-maintaining diet, the researchers found that the hypercaloric diet was associated with suppressed fatty acid oxidation the next morning (187 versus 237 umol/minute). But they found that a single session of exercise after a hypercaloric diet was associated with increased fatty acid oxidation (293 umol/min). They also found a direct correlation between fatty acid uptake and muscle glycerol-3-phosphate acyltransferase activity, which catalyzes the first step in intramyocellular triglyceride concentration synthesis.

"Exercise decreases everyone's insulin resistance and therefore reduces the chances of developing diseases such as type 2 diabetes," Cornford said in a statement. "This study shows that even a single bout of exercise helps obese individuals increase their body's fat-burning rate and improve their metabolic health."

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