WEDNESDAY, May 19 (HealthDay News) -- In women with heavy menstrual bleeding, a novel, oral tranexamic acid formulation may improve quality of life, according to research presented this week at the annual meeting of the American College of Obstetricians and Gynecologists in San Francisco.
Andrea Lukes, M.D., of the Carolina Women's Research and Wellness Center in Durham, N.C., and colleagues randomly assigned 294 women aged 18 to 49 with a mean menstrual blood loss of more than 80 mL per cycle to receive 1.95 or 3.9 grams per day of tranexamic acid, or placebo, for up to five days per menstrual cycle for three cycles.
Compared to placebo, the researchers found that both doses of tranexamic acid were associated with significant improvements in quality of life as measured by the Menorrhagia Impact Questionnaire. They also found that the higher dose was associated with greater improvements than the lower dose, and that both dosage regimens were well tolerated.
"The Menorrhagia Impact Questionnaire contains questions regarding limitations on social-leisure, physical, or work activities during menstruation as well as the woman's perception of the influence of menstrual blood loss on quality of life," the authors write.
Abstract - Lukes
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