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Polycystic Ovary Syndrome Tied to Diabetes, Dyslipidemia

Women with PCOS have higher odds of incident diabetes and dyslipidemia independent of BMI

TUESDAY, Dec. 28 (HealthDay News) -- Women with polycystic ovary syndrome (PCOS) appear to be at a higher risk of diabetes and dyslipidemia, independent of body mass index (BMI), according to a study published in the January issue of Obstetrics & Gynecology.

Erica T. Wang, M.D., of the University of California in San Francisco, and colleagues estimated the association of PCOS with incident diabetes, dyslipidemia, and hypertension over a period of 18 years among 1,127 white and African-American women (aged 20 to 32 at baseline) in the Coronary Artery Risk Development in Young Adults cohort. The investigators also estimated the association of persistent PCOS with cardiovascular risk factors among 746 women with a second assessment of PCOS between the ages of 34 and 46.

Over the course of 18 years, the investigators found that those with PCOS had two-fold higher odds of incident diabetes than those without PCOS (23.1 versus 13.1 percent). The condition was also associated with higher odds of dyslipidemia (41.9 versus 27.7 percent). However, PCOS was not significantly associated with incident hypertension. Normal-weight women with PCOS had three-fold higher odds of incident diabetes compared with normal-weight women without the condition. In addition, women with persistent PCOS had the highest odds of diabetes compared with those without the condition (adjusted odds ratio, 7.2).

"PCOS is associated with subsequent incident diabetes and dyslipidemia, independent of BMI. Diabetes risk may be greatest for women with persistent PCOS symptoms," the authors write.

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