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Older Data Shows Aspirin Use Not Linked to Miscarriage

Prospective data from 1960s study shows miscarriage rate with aspirin use same as controls

WEDNESDAY, July 5 (HealthDay News) -- Aspirin use is not associated with an increased risk of miscarriage, according to a study in the July issue of Epidemiology that examined data from a perinatal study conducted in the early 1960s, when aspirin use was common.

Sarah A. Keim, M.A., and Mark A. Klebanoff, M.D., from the National Institute of Child Health and Human Development in Bethesda, Md., conducted a case-control study using prospectively collected data from about 54,000 women enrolled in the Collaborative Perinatal Project from 1959 to 1965 to evaluate the association between aspirin use and miscarriage.

Around 29 percent of the 542 women who had miscarriages used aspirin during their pregnancy, compared with 34 percent of 2,587 matched controls. In fact, the odds ratios for miscarriage with aspirin use were less than 1.0 for individual lunar months and combinations of lunar months, ranging from 0.64 to 0.92.

Although the data is from an older cohort, the authors state that aspirin use was more prevalent during this time and that there was less concern about drug use during pregnancy in general. Because previous studies of NSAID use, including aspirin, and miscarriage have found opposite results, future research should confirm that its deliberate use is not harmful to pregnancy, the researchers suggest.

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