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Donor Oocytes Linked to Hypertension in Pregnancy

Pregnancy-induced hypertension, preterm and Caesarean deliveries up in oocyte recipients

THURSDAY, April 19 (HealthDay News) -- Women who use donor oocytes, particularly younger women, have higher rates of pregnancy-induced hypertension and other obstetric problems than those who undergo in vitro fertilization, according to a report in the April issue of Fertility and Sterility.

Debbra A. Keegan, M.D., from New York University Medical Center in New York City, and colleagues conducted a retrospective anonymous questionnaire study of 199 oocyte donation recipients and 488 in vitro fertilization patients to compare the obstetric outcomes. Sixty percent responded to the questionnaire.

Overall, 42 percent of oocyte recipients who were younger than 35 years had pregnancy-induced hypertension, compared with 26 percent of oocyte recipients 40 years and older, 14 percent of older IVF patients, and 12 percent of younger IVF patients. Preterm delivery rates, Caesarean rates for singleton pregnancies, and twin deliveries, were higher in the oocyte group compared with similar age IVF patients.

"Based on our findings and existing literature, we believe oocyte donation recipients, particularly young women, may be at higher risk for pregnancy-induced hypertension," the authors concluded. "In addition to pregnancy-induced hypertension, any woman electing oocyte donation as a means to family building should be counseled regarding the potential risks of twin delivery, Caesarean section, and pre-term delivery."

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