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Gonadotrophin Linked to Acceptable Multiple Birth Rate

But only in women who have one or two mature follicles at the time of insemination

TUESDAY, Dec. 25 (HealthDay News) -- In women with one or two mature ovarian follicles measuring 14 millimeters or more, treatment of intrauterine insemination with gonadotrophin results in an acceptable multiple live birth rate, according to research published in the December issue of the American Journal of Obstetrics & Gynecology.

Sophie L. Ghesquiere, M.D., of the Leuven University Fertility Center in Leuven, Belgium, and colleagues studied outcomes in 2,463 intrauterine insemination cycles, including 118 performed during a natural cycle, 663 performed after controlled ovarian hyperstimulation with clomiphene citrate, and 1,682 performed after controlled ovarian hyperstimulation with gonadotrophins.

The researchers found that the multiple live birth rate per cycle was significantly higher after stimulation with gonadotrophins than with clomiphene cirate (13 percent versus 8 percent) if only one follicle measuring at least 14 mm was present. But when two or more follicles were present, they found no significant differences in multiple live birth rates between the two stimulation methods.

"Our results suggest that intrauterine insemination with gonadotrophin is an effective treatment with an acceptable multiple live birth rate (6 percent) as long as the stimulation is carefully monitored and only one or maximum two follicles 14 mm or larger are present at the time of insemination," the authors conclude.

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